P87312

PR
Gene name
SPBC31F10.10c
Protein name
Pre-mRNA-splicing factor cwf4
Names
Complexed with cdc5 protein 4
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC31F10.11c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-85 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P87312

Entry ID Method Resolution Chain Position Source
3JB9 EM 360 A R 41-290 PDB
AF-P87312-F1 Predicted AlphaFoldDB

No variants for P87312

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P87312

No associated diseases with P87312

1 regional properties for P87312

Type Name Position InterPro Accession
domain Sulfotransferase domain 36 - 281 IPR000863

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
post-mRNA release spliceosomal complex A spliceosomal complex that is formed following the release of the spliced product from the post-spliceosomal complex and contains the excised intron and three snRNPs, including U5.
Prp19 complex A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p.
spliceosomal complex Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA.
U2-type catalytic step 2 spliceosome A spliceosomal complex that contains the U2, U5 and U6 snRNPs bound to a splicing intermediate in which the first catalytic cleavage of the 5' splice site has occurred. The precise subunit composition differs significantly from that of the catalytic step 1, or activated, spliceosome, and includes many proteins in addition to those found in the U2, U5 and U6 snRNPs.
U2-type prespliceosome A spliceosomal complex that is formed by association of the 5' splice site with the U1 snRNP, while the branch point sequence is recognized by the U2 snRNP. The prespliceosome includes many proteins in addition to those found in the U1 and U2 snRNPs. Commitment to a given pair of 5' and 3' splice sites occurs at the time of prespliceosome formation.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
mRNA cis splicing, via spliceosome The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
spliceosomal complex assembly The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSEAPRVKN KNPAPIQISA EQLLREAVER QDVAFVPPKI NITDLEELQE FQGRKRKEFE
70 80 90 100 110 120
DAIRRNRLAM GHWMRYGQWE LDQKEFARAR SVFERALDVD STYIPLWLKY IECEMKNRNI
130 140 150 160 170 180
NHARNLFDRA VTQLPRVDKL WYKYVYMEEM LGNITGCRQV FERWLKWEPD ENCWMSYIRM
190 200 210 220 230 240
ERRYHENERA RGIYERFVVV HPEVTNWLRW ARFEEECGNA ANVRQVYLAA IDALGQEFLN
250 260 270 280 290 300
ERFFIAFAKF EIRQKEYERA RTIFKYAIDF MPRSKSMELY KEYTHFEKQF GDHLGVESTV
310 320 330 340 350 360
LDKRRLQYEK LLKDSPYDYD TWLDLLKLEE SAGDINTIRE TYEKAIAKVP EVVEKNAWRR
370 380 390 400 410 420
YVYIWLNYCL FEEIDVKDVD RARKVYQEAL KLIPHKKFTF AKLWLMYAMF ELRQRKIDVA
430 440 450 460 470 480
RKTLGRALGM CPKPKLFRGY IEFEDAIKQF DRCRILYEKW ILYDPEACAP WLGYAALETK
490 500 510 520 530 540
LGDSDRARAL YNLAVNQPIL ETPELVWKAY IDFEFEEMEY GKARSIYQQL LRTAPHVKVW
550 560 570 580 590 600
ISFANFEIAH LEDDDEEPPN EEVASPTAVV RARNVFENAL AHLRQQGLKE ERVVLLEAWK
610 620 630 640 650 660
QFEAMHGTED TRKHVSSLMP QVVKKRRRLE DGSFEEYLDY LFPDTATDQG DKMRKMLELS
670
RKWKEEMAKK KLEA