P87305

PR
Gene name
SPBC31F10.02
Protein name
Glutathione-specific gamma-glutamylcyclotransferase
Names
Gamma-GCG
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPBC31F10.03
EC number
4.3.2.7: Lyases acting on amides, amidines, etc
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

110-180 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P87305

Entry ID Method Resolution Chain Position Source
AF-P87305-F1 Predicted AlphaFoldDB

No variants for P87305

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P87305

No associated diseases with P87305

1 regional properties for P87305

Type Name Position InterPro Accession
domain Gamma-glutamyl cyclotransferase-like 12 - 135 IPR013024

Functions

Description
EC Number 4.3.2.7 Lyases acting on amides, amidines, etc
Subcellular Localization
  • Cytoplasm
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
gamma-glutamylcyclotransferase activity Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid.
glutaminyl-peptide cyclotransferase activity Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3.
glutathione specific gamma-glutamylcyclotransferase activity Catalysis of the reaction: glutathione = 5-oxoproline + L-cysteinylglycine.

2 GO annotations of biological process

Name Definition
cellular detoxification Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance.
glutathione catabolic process The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTLSPEGSL WVFGYGSLIW HPPPHYDYSI PCFIKGYVRR FWMRSEDHRG TVNSPGLVLT
70 80 90 100 110 120
LIPYEEWKQF SDWSFTPFDE GCWGMAFRIP AKYATQVREY LDDREVNGYT AHSVPVYAHT
130 140 150 160 170 180
GDEIPVLENC LVYVGTSKSP QFQPSDDLTQ MAKIISTRRG KSGDNFVYLF ELAKCLRHLS
190 200
PESKDIHVFE LEAEVRKQMQ KTR