P87244
PR
Gene name |
rix1 (SPCC4G3.18) |
Protein name |
Spindle pole body component alp16 |
Names |
Altered polarity protein 16 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPCC4G3.19 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P87244
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P87244-F1 | Predicted | AlphaFoldDB |
No variants for P87244
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P87244 | |||||
No associated diseases with P87244
No regional properties for P87244
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P87244 | |||
8 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| equatorial microtubule organizing center | A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis. |
| gamma-tubulin complex | A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species. |
| gamma-tubulin large complex | A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe. |
| gamma-tubulin small complex | A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. |
| microtubule | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. |
| mitotic spindle pole body | The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome. |
| spindle pole | Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| gamma-tubulin binding | Binding to the microtubule constituent protein gamma-tubulin. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| cytoplasmic microtubule organization | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell. |
| meiotic cell cycle | Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions. |
| microtubule nucleation | The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation). |
| microtubule nucleation by interphase microtubule organizing center | The 'de novo' formation of a microtubule by the interphase microtubule organizing center during interphase, the stage of cell cycle between successive rounds of chromosome segregation. |
| mitotic cell cycle | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. |
| spindle assembly | The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MDGIMKNDLL | WFGNHVFDLT | PNSFDSDFVE | QLSKFEGKEG | LKRKLFDSSE | YFQNFSFQVN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDLLGKDVIL | DISNQQLTPA | VPGCETSSNS | KLISASKEIT | SERKRAKSSV | SPSYLTDSSP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| SDLSVENKVL | LTCPSWDGEN | FKNLEARSPF | ISEAPSRVYD | YFLHNQDWSP | KPLFSALQVY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PLATIFNCVA | GLPQGFESTV | FPWNKTSSTF | ELDPTISVSG | MSDECFASIV | QKFSAIGGLI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KKALNEFSLY | KTNISFYLSN | FIVNGVLQYR | KEFQRWLRLY | EFRRFGLIGL | SNFVNSFSSF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FELISHFLIK | SAQNLKGDSL | LDFLFDYARS | CQNTISYPIA | LQCLIYCSNP | YFKRLELALK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VSCAYGHIDS | SLFLSLPRFF | PSELCVSIEQ | CIQFLSLIRE | QKEIFNKNNK | EFINPLNIRF |
| 430 | 440 | 450 | 460 | 470 | 480 |
| AYSFNDINQA | CVIEERCNFS | SLSFGNLEQT | SVNNDSEEFE | TLLAKMNMTP | DFNDNLLQLK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| FTDDVRNVCP | LNLNVCCCIA | EPIQSFILSF | LRSTYKVLKN | DFQVFDLLNF | FHSTFLFQNY |
| 550 | 560 | 570 | 580 | 590 | 600 |
| EFSDNVISLL | KSRRLDKSDR | NELAEDLNSD | DRYNFISRLK | KFIFMEKEKN | GLSRSLSKSI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TFTLDSASVS | EFEDVYPDLQ | FQCQVIGALR | ILFTDNSLNY | YSKTFSYVLH | LFQAQSDFES |
| 670 | 680 | 690 | 700 | 710 | 720 |
| SVELKDRSIV | TKTTIMSWSK | YQGTKESLFQ | FLSIYIPECM | LPFTKLLKSI | YSPDCPTNIQ |
| 730 | 740 | 750 | |||
| NSAIKNAASV | HEQCTKAIYQ | KVKELFDTMK | LWESSIKVS |