P87228

PR
Gene name
mis6 (SPAC1687.20c)
Protein name
Putative D-3-phosphoglycerate dehydrogenase
Names
3-PGDH, 2-oxoglutarate reductase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC364.07
EC number
1.1.1.399: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-80 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P87228

Entry ID Method Resolution Chain Position Source
AF-P87228-F1 Predicted AlphaFoldDB

No variants for P87228

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P87228

No associated diseases with P87228

2 regional properties for P87228

Type Name Position InterPro Accession
domain Septum formation inhibitor MinC, C-terminal 109 - 207 IPR005526
domain Septum formation inhibitor MinC, N-terminal 11 - 75 IPR007874

Functions

Description
EC Number 1.1.1.399 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

4 GO annotations of molecular function

Name Definition
glyoxylate reductase (NADP+) activity Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+.
hydroxypyruvate reductase activity Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
phosphoglycerate dehydrogenase activity Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+.

1 GO annotations of biological process

Name Definition
L-serine biosynthetic process The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDIKGGRRGN VEDSLNKLSL SPPDNNSSFL SNHFQVRKSY SQAPARTLKP FASEDIKILL
70 80 90 100 110 120
LENVNQSALS NLKDEGYQVE FLKTSMSEDD LVEKIKGVHA IGIRSKTRLT RRVLEAADSL
130 140 150 160 170 180
IVIGCFCIGT NQVDLDFAAE RGIAVFNSPY ANSRSVAELV IGYIISLARQ VGDRSLELHR
190 200 210 220 230 240
GEWNKVSSGC WEIRGKTLGI IGYGHIGSQL SVLAEAMGLH VVYYDILPIM PLGSAKQLSS
250 260 270 280 290 300
LPELLHRADF VSLHVPASPE TKNMISSKEF AAMKEGSYLI NASRGTVVDI PALVDASKSG
310 320 330 340 350 360
KIAGAAIDVY PSEPAGNGKD KFVDSLNSWT SELTHCKNII LTPHIGGSTE EAQYNIGIEV
370 380 390 400 410 420
SEALTRYINE GNSIGAVNFP EVSLRSLTEA DRNAARVLFV HRNVPGVLRQ VNELFIDHNI
430 440 450 460
KSQFSDSRGD IAYLVADISD CTPGSLEALH QKLESLPCKI NTRLLY