P87220
Gene name |
SOU1 (CAALFM_C406390WA, CaO19.10414, CaO19.2896) |
Protein name |
V-type proton ATPase subunit D |
Names |
V-ATPase subunit D, Vacuolar proton pump subunit D |
Species |
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) |
KEGG Pathway |
cal:CAALFM_C406400CA |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P87220
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P87220-F1 | Predicted | AlphaFoldDB |
No variants for P87220
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P87220 | |||||
No associated diseases with P87220
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| fungal-type vacuole membrane | The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae. |
| proton-transporting V-type ATPase complex | A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
| vacuolar proton-transporting V-type ATPase complex | A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen. |
| vacuolar proton-transporting V-type ATPase, V1 domain | The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| proton-transporting ATPase activity, rotational mechanism | Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| vacuolar acidification | Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSGAGNREQV | FPTRMTLGVM | KSKLKGAQQG | HSLLKRKSEA | LTKRFRDITQ | RIDDAKRKMG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| RVMQTAAFSL | AEVQYATGDN | ISYQVQESVQ | KARFTVKAKQ | ENVSGVFLPT | FDSHINEDVN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DFKLTALARG | GQQVQKAKLI | YSKAVETLVE | LASLQTAFII | LDEVIKITNR | RVNAIEHVII |
| 190 | 200 | 210 | 220 | 230 | 240 |
| PRTENTIAYI | NGELDEMDRE | EFYRLKKVQE | KKQEAAAAAE | QEEALAKAKA | EGATDELAIQ |
| 250 | 260 | ||||
| QDVEALDIKA | DKEEVDILQE | KEDDVIF |