P87140

PR
Gene name
SPAC57A7.09
Protein name
Probable coatomer subunit gamma
Names
Gamma-coat protein, Gamma-COP
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC57A7.10c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-56 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P87140

Entry ID Method Resolution Chain Position Source
AF-P87140-F1 Predicted AlphaFoldDB

6 variants for P87140

Variant ID(s) Position Change Description Diseaes Association Provenance
I_1522189_T_G 145 I>S No Jeffares_SNPs
I_1522596_A_G 281 S>G No Jeffares_SNPs
I_1522905_A_G 384 I>V No Jeffares_SNPs
I_1523560_T_C 602 V>A No Jeffares_SNPs
I_1524171_A_G 786 D>G No Jeffares_SNPs
I_1524242_C_T 810 L>F No Jeffares_SNPs

No associated diseases with P87140

3 regional properties for P87140

Type Name Position InterPro Accession
domain Clathrin/coatomer adaptor, adaptin-like, N-terminal 21 - 560 IPR002553
domain Coatomer, gamma subunit, appendage, Ig-like subdomain 646 - 790 IPR013040
domain Coatomer subunit gamma, C-terminal 792 - 903 IPR032154

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Golgi apparatus membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasmic vesicle, COPI-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side
  • The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
COPI vesicle coat One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum-Golgi intermediate compartment A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.

1 GO annotations of molecular function

Name Definition
structural molecule activity The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell.

5 GO annotations of biological process

Name Definition
endoplasmic reticulum to Golgi vesicle-mediated transport The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
intra-Golgi vesicle-mediated transport The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network).
intracellular protein transport The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell.
protein secretion The controlled release of proteins from a cell.
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYSKKDDDG DESIFANVNQ VTVTQDARAF NSSSISPRKS RRLLSKIAYL IYTGEHFQEK
70 80 90 100 110 120
QATELFFGIT KLFQHKDPSL RQFVYIIIKE LSVVAEDVIM ITSSIMKDTA TGRETIYRPN
130 140 150 160 170 180
AIRSLIRVID ANTVPAIERI LTTGIVDPIS AVASAALVSA YHLYPVAKDI VSRWNNEVQD
190 200 210 220 230 240
AVTSHNVGRK VASSPFFTST LGYTPNASGI SQYHALGLLY RIRRHDSIAM NKLLQLLVSN
250 260 270 280 290 300
LGTVSNSHAF VMLIRYISSL MDQNTQFRDQ MVPFLHGWLK SKGDMVNLEV ARNMVRLKNI
310 320 330 340 350 360
SDDDLQPVVS VLKIFLSSHR SATRFSAIRT LNELAMTRPH LVHSCNLNIE SLITDVNRSI
370 380 390 400 410 420
ATYAITTLLK TGNDESVDRL MKQIVTFMSD ISDNFKIIVV DAIRSLCLKF PRKQDSMLTF
430 440 450 460 470 480
LSNILCDEGG YEFKRAAVDA ISDMIKYIPE SKERALAELC EFIEDCEYPK IAVRILSILG
490 500 510 520 530 540
EEGPKASEPT RFIRYIYNRI MLENAIVRSA AVSALTKFGL NAEDKFVQRS VKVILTRCLE
550 560 570 580 590 600
DADDEVRDRA AFSVKALEDR DAFLPVVKSD KIPSLPALER SLVIYISERK FGQGFDIKSV
610 620 630 640 650 660
PVLSQEEIDA ENLRIKKATT EVEFTEVTPA EDQNALASSN IETEFLNALE SVSEFNEYGP
670 680 690 700 710 720
VLKSSPSPIE LTEQETEFVV KVVKHVFKDH LVVQFQLHNT LSEVILENAV VVSTPSTDDL
730 740 750 760 770 780
VEECVVPAAI VSGEPVSIFV SFKFNDSVPY PLTTLTNTLQ FTTKEIDIHT GEPEEEGYED
790 800 810 820 830 840
EYKIDDLDVS AGDFISPAYE SNFDGLFDSL EHEASEVYVL SLLDSFRSTC SRVAELLQMQ
850 860 870 880 890 900
PLEGTENPTD KPVHVMKLSG KLVNGEKVLA LVKMAHSKDG EGITIKVIAR GESDSSVELV
VGGIA