P87115

PR
Gene name
nat10
Protein name
RNA cytidine acetyltransferase
Names
18S rRNA cytosine acetyltransferase
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC20G8.09c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

39-115 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P87115

Entry ID Method Resolution Chain Position Source
AF-P87115-F1 Predicted AlphaFoldDB

6 variants for P87115

Variant ID(s) Position Change Description Diseaes Association Provenance
I_1417982_G_C 221 P>R No Jeffares_SNPs
I_1417536_T_G 370 S>R No Jeffares_SNPs
I_1416654_T_C 664 K>E No Jeffares_SNPs
I_1416193_G_T 817 N>K No Jeffares_SNPs
I_1415919_T_C 909 I>V No Jeffares_SNPs
I_1415634_T_C 1004 I>V No Jeffares_SNPs

No associated diseases with P87115

1 regional properties for P87115

Type Name Position InterPro Accession
conserved_site Mrp, conserved site 184 - 200 IPR000808

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
90S preribosome A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
rRNA cytidine N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA.
tRNA binding Binding to a transfer RNA.
tRNA N-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of a tRNA.

2 GO annotations of biological process

Name Definition
rRNA acetylation involved in maturation of SSU-rRNA Any rRNA acetylation that is involved in maturation of SSU-rRNA.
tRNA acetylation The modification of tRNA structure by addition of an acetyl group to tRNA. An acetyl group is CH3CO-, derived from acetic

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPKKALDSRI PTLIKNGCQE KQRSFFVVVG DRARDQVVNL HWLLSQSKVA ARPNVLWMYK
70 80 90 100 110 120
KDLLGFTSHR KKRENKIKKE IKRGIRDPNS EDPFELFCSI TNIRYCYYKE SEKILGQTYG
130 140 150 160 170 180
MLVLQDFEAL TPNLLARTIE TVEGGGIVVL LLHKLNSLKQ LYTMSMDIHS RYRTEAHSDV
190 200 210 220 230 240
TARFNERFIL SLGNCENCLV IDDELNVLPI SGGKNVKALP PTLEEDNSTQ NSIKELQESL
250 260 270 280 290 300
GEDHPAGALV GVTKTLDQAR AVLTFVESIV EKSLKGTVSL TAGRGRGKSA ALGLAIAAAI
310 320 330 340 350 360
AHGYSNIFIT SPSPENLKTL FEFIFKGFDA LNYEEHVDYD IIQSTNPAYH NAIVRVNIFR
370 380 390 400 410 420
DHRQTIQYIS PEDSNVLGQA ELVVIDEAAA IPLPLVRKLI GPYLVFMAST INGYEGTGRS
430 440 450 460 470 480
LSLKLLQQLR EQSRIYSGSG NNKSDSQSHI SGRTLKEISL DEPIRYAMGD RIELWLNKLL
490 500 510 520 530 540
CLDAASYVSR MATQGFPHPS ECSLYRVSRD TLFSYHPISE AFLQRMMSLY VASHYKNSPN
550 560 570 580 590 600
DLQLMSDAPA HQLFVLLPPV DLKNPKLPDP ICVIQLALEG SISRESIMNS LSRGQRAGGD
610 620 630 640 650 660
LIPWLISQQF QDENFAALGG ARIVRIAVSP EHVKMGYGTR AMQLLHEYFE GKFISASEEF
670 680 690 700 710 720
KAVKHSLKRI GDEEIENTAL QTEKIHVRDA KTMPPLLLKL SELQPEPLHY VGVSYGLTPS
730 740 750 760 770 780
LQKFWKREGY CPLYLRQTAN DLTGEHTCVM LRVLEGRDSE WLGAFAQNFY RRFLSLLGYQ
790 800 810 820 830 840
FREFAAITAL SVLDACNNGT KYVVNSTSKL TNEEINNVFE SYDLKRLESY SNNLLDYHVI
850 860 870 880 890 900
VDLLPKLAHL YFSGKFPDSV KLSPVQQSVL LALGLQYKTI DTLEKEFNLP SNQLLAMLVK
910 920 930 940 950 960
LSKKIMKCID EIETKDIEEE LGSNKKTESS NSKLPEFTPL QQSLEEELQE GADEAMLALR
970 980 990 1000 1010 1020
EKQRELINAI DLEKYAIRGN EEDWKAAENQ IQKTNGKGAR VVSIKGEKRK NNSLDASDKK
1030
TKEKPSSKKK FRK