P87110

PR
Gene name
SPAC20G8.02
Protein name
Myo-inositol transporter 2
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC20G8.03
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P87110

Entry ID Method Resolution Chain Position Source
AF-P87110-F1 Predicted AlphaFoldDB

9 variants for P87110

Variant ID(s) Position Change Description Diseaes Association Provenance
I_1394019_A_T 42 M>L No Jeffares_SNPs
I_1394029_T_C 45 I>T No Jeffares_SNPs
I_1394049_G_A 52 E>K No Jeffares_SNPs
I_1394080_A_G 62 N>S No Jeffares_SNPs
I_1394643_G_A 250 A>T No Jeffares_SNPs
I_1394872_T_C 326 V>A No Jeffares_SNPs
I_1394976_A_G 361 S>G No Jeffares_SNPs
I_1395067_G_A 391 R>H No Jeffares_SNPs
I_1395558_G_T 555 D>Y No Jeffares_SNPs

No associated diseases with P87110

3 regional properties for P87110

Type Name Position InterPro Accession
conserved_site Sugar transporter, conserved site 140 - 156 IPR005829-1
conserved_site Sugar transporter, conserved site 385 - 402 IPR005829-2
domain Major facilitator superfamily domain 84 - 523 IPR020846

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
myo-inositol:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in).
transmembrane transporter activity Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
myo-inositol import across plasma membrane The directed movement of myo-inositol from outside of a cell, across the plasma membrane and into the cytosol.
transmembrane transport The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDFNNIPLAT IKSSDDKGKD FIVEMTTRPS ETKKKVPFSE DMREIPSLPN EEEANATDPQ
70 80 90 100 110 120
ANEVADENGE GFEAEKISSW IWVLSAVAGI SGLLFGYDTG VISGALAVLG SDLGHVLSSG
130 140 150 160 170 180
QKELITSATS FAALISATTS GWLADWVGRK RLLLCADAIF VIGSVIMAAS RNVAMMVVGR
190 200 210 220 230 240
FIVGYGIGLT SLIVPMYITE LAPARLRGRL VIIYVVFITG GQLIAYSLNA AFEHVHQGWR
250 260 270 280 290 300
IMFGIGAAPA LGQLISLFWT PESPRYLLRH NHVEKVYKIL SRIHPEAKPA EIAYKVSLIQ
310 320 330 340 350 360
EGVKVDFPEG NKFQHFFHSL KVLFTVPSNR RSLFIGCFLQ WFQQFSGTNA IQYFSAIIFQ
370 380 390 400 410 420
SVGFKNSISV SIVVGATNFV FTIVAFMFID RIGRRRILLC TSAVMIAGLA LCAIAYHFLP
430 440 450 460 470 480
ADTTQNTNSG WQYVVLASII IFLASYASGI GNIPWQQAEL FPMEVRALGA GFSTAINWVG
490 500 510 520 530 540
NLIISASFLT MMESITPTGT FALFAGFCFV GLVTSYFTYP ELAGMSIENI HKLLEKGFWQ
550
AVKESTKRVR KGRIDEA