P87058
Gene name |
nhp6 (SPAC57A10.09c) |
Protein name |
La protein homolog |
Names |
La autoantigen homolog, La ribonucleoprotein |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC57A10.10c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P87058
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P87058-F1 | Predicted | AlphaFoldDB |
5 variants for P87058
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_1383434_T_C | 27 | E>G | No | Jeffares_SNPs | |
| I_1383315_C_G | 67 | V>L | No | Jeffares_SNPs | |
| I_1383020_A_C | 140 | M>R | No | Jeffares_SNPs | |
| I_1382820_G_A | 207 | P>S | No | Jeffares_SNPs | |
| I_1382582_G_T | 286 | S>Y | No | Jeffares_SNPs |
No associated diseases with P87058
4 regional properties for P87058
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Xylose isomerase-like, TIM barrel domain | 20 - 277 | IPR013022 |
| binding_site | AP endonuclease 2, zinc binding site | 69 - 77 | IPR018246-1 |
| binding_site | AP endonuclease 2, zinc binding site | 175 - 182 | IPR018246-2 |
| binding_site | AP endonuclease 2, zinc binding site | 215 - 231 | IPR018246-3 |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| ribonucleoprotein complex | A macromolecular complex that contains both RNA and protein molecules. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA strand annealing activity | An activity that facilitates the formation of a complementary double-stranded RNA molecule. |
| tRNA binding | Binding to a transfer RNA. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA 3'-end processing | The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA. |
| tRNA 5'-leader removal | Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P. |
| tRNA folding | The process of assisting in the folding of tRNAs into the correct tertiary structure. |
| tRNA processing | The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSTEEQKEEI | KDISSKQENS | SEVPKAEEAG | KVVESQKDTT | SEEKKEETTE | KKEDDGKKDL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SFDEAEVLKQ | VEFYFSDTNL | PHDKFLWTTS | QKNDGWVPIQ | TIANFKRMRR | FQPLEAIVNA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LRKSPELLEV | DEAGEKVRRM | IPLVRVDNKS | VMERSVYCKG | FGDEKDDTQI | ALEKFFEENA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GPISAVRMRR | DDDKKFKGSV | FVEFKEPDVA | NKFLEKVKTA | PLKWGEDELT | IMSKKEYVDM |
| 250 | 260 | 270 | 280 | 290 | |
| KAELHKNDPP | KFSSKRRRFD | AFKEMDRQRP | GKYSNRGRKF | KKQRSSNASE | EKPSAASE |