P83453
Gene name |
tyrS |
Protein name |
Tyrosine--tRNA ligase |
Names |
Tyrosyl-tRNA synthetase, TyrRS |
Species |
Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) |
KEGG Pathway |
tth:TT_C1033 |
EC number |
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
3 structures for P83453
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 1H3E | X-ray | 290 A | A | 1-432 | PDB |
| 1H3F | X-ray | 200 A | A/B | 1-432 | PDB |
| AF-P83453-F1 | Predicted | AlphaFoldDB |
No variants for P83453
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P83453 | |||||
No associated diseases with P83453
No regional properties for P83453
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P83453 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.1 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| tyrosine-tRNA ligase activity | Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tyrosyl-tRNA aminoacylation | The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGTGHTPEE | ALALLKRGAE | EIVPEEELLA | KLKEGRPLTV | KLGADPTRPD | LHLGHAVVLR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KMRQFQELGH | KVVLIIGDFT | GMIGDPSGRS | KTRPPLTLEE | TRENAKTYVA | QAGKILRQEP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HLFELRYNSE | WLEGLTFKEV | VRLTSLMTVA | QMLEREDFKK | RYEAGIPISL | HELLYPFAQA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YDSVAIRADV | EMGGTDQRFN | LLVGREVQRA | YGQSPQVCFL | MPLLVGLDGR | EKMSKSLDNY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IGLTEPPEAM | FKKLMRVPDP | LLPSYFRLLT | DLEEEEIEAL | LKAGPVPAHR | VLARLLTAAY |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ALPQIPPRID | RAFYESLGYA | WEAFGRDKEA | GPEEVRRAEA | RYDEVAKGGI | PEEIPEVTIP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ASELKEGRIW | VARLFTLAGL | TPSNAEARRL | IQNRGLRLDG | EVLTDPMLQV | DLSRPRILQR |
| 430 | |||||
| GKDRFVRVRL | SD |