P83370

PR
Gene name
Protein name
Venom prothrombin activator hopsarin-D
Names
vPA, Venom coagulation factor Xa-like protease
Species
Hoplocephalus stephensii (Stephens' banded snake)
KEGG Pathway
EC number
3.4.21.6: Serine endopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

155-232 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P83370

Entry ID Method Resolution Chain Position Source
AF-P83370-F1 Predicted AlphaFoldDB

No variants for P83370

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P83370

No associated diseases with P83370

1 regional properties for P83370

Type Name Position InterPro Accession
domain Transposase IS4-like domain 119 - 385 IPR002559

Functions

Description
EC Number 3.4.21.6 Serine endopeptidases
Subcellular Localization
  • Secreted
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

4 GO annotations of molecular function

Name Definition
calcium ion binding Binding to a calcium ion (Ca2+).
peptidase activator activity Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
serine-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
toxin activity Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom.

4 GO annotations of biological process

Name Definition
blood coagulation The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
envenomation resulting in positive regulation of blood coagulation in another organism A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of blood coagulation in the bitten organism.
positive regulation of blood coagulation in another organism Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAPQLLLCLI LTFLWSVPEA ESNVFLKSKV ANRFLQRTKR SNSLFEEIRP GNIERECIEE
70 80 90 100 110 120
KCSKEEAREV FEDNEKTETF WNVYVDGDQC SSNPCHYHGT CKDGIGSYTC TCLPNYEGKN
130 140 150 160 170 180
CEKVLFKSCR AFNGNCWHFC KRVQSETQCS CAESYRLGVD GHSCVAEGDF SCGRNIKARN
190 200 210 220 230 240
KREASLPDFV QSQKATLLKK SDNPSPDIRI VNGMDSKLGE CPWQAVLINE KGEVFCGGTI
250 260 270 280 290 300
LSPIHVLTAA HCINQTKSVS VIVGEIDISR KETRRLLSVD KIYVHTKFVP PNYYYGHQNF
310 320 330 340 350 360
DRVAYDYDIA IIRMKTPIQF SENVVPACLP TADFANEVLM KQDSGIVSGF GRIRFKEPTS
370 380 390 400 410 420
NTLKVITVPY VDRHTCMLSS DFRITQNMFC AGYDTLPQDA CEGDSGGPHI TAYGDTHFIT
430 440 450
GIVSWGEGCA RKGKYGVYTK VSRFIPWIKK IMSLK