P81910
PR
Gene name |
Or22b |
Protein name |
Odorant receptor 22b |
Names |
|
Species |
Drosophila melanogaster (Fruit fly) |
KEGG Pathway |
dme:Dmel_CG4231 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P81910
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P81910-F1 | Predicted | AlphaFoldDB |
37 variants for P81910
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| 3 | S>G | strain: MA7 [UniProt] | No | ||
| 4 | Q>K | strain: LA116, MA18, MA45, MA48, MA50, MA7, MA8, MW25, MW29, MW3, MW32, MW37, MW44, MW46, MW56, MW6, MW7, MW9, NC21a, NC52a, NC62a, NC73a and NC79b [UniProt] | No | ||
| 25 | V>I | strain: LA116, MA13, MA18, MA43, MA45, MA48, MA50, MA7, MA74, MA8, MW25, MW27, MW29, MW3, MW32, MW37, MW44, MW46, MW56, MW6, MW7, MW9, NC21a, NC52a, NC62a, NC73a and NC79b [UniProt] | No | ||
| 30 | V>L | strain: NC52a and NC73a [UniProt] | No | ||
| 38 | V>E | strain: NC21a, NC52a, NC62a, NC73a and NC79b [UniProt] | No | ||
| 45 | D>I | strain: LA116, MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 47 | H>P | strain: LA116 [UniProt] | No | ||
| 69 | V>A | strain: MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 87 | I>L | strain: LA116 [UniProt] | No | ||
| 88 | Q>E | strain: LA116 [UniProt] | No | ||
| 92 | N>D | strain: NC21a, NC52a, NC62a, NC73a and NC79b [UniProt] | No | ||
| 93 | M>V | strain: LA116 [UniProt] | No | ||
| 101 | Y>C | strain: MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 102 | L>F | strain: MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 111 | Q>E | strain: MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 126 | C>R | strain: MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 140 | G>A | strain: LA9 [UniProt] | No | ||
| 150 | A>L | strain: MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 156 | I>F | strain: MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 157 | S>T | strain: MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 167 | I>V | strain: MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 194 | R>M | strain: LA116, MA13, MA18, MA43, MA45, MA48, MA50, MA7, MA74, MA8, MW25, MW27, MW29, MW3, MW32, MW37, MW44, MW46, MW56, MW6, MW7, MW9, NC21a, NC52a, NC62a, NC73a and NC79b [UniProt] | No | ||
| 196 | W>L | strain: LA116 [UniProt] | No | ||
| 201 | D>A | strain: NC21a, NC52a, NC62a, NC73a and NC79b [UniProt] | No | ||
| 213 | V>L | strain: LA116, MA45, MA50, MW37, MW6, MW9, NC52a and NC73a [UniProt] | No | ||
| 214 | I>M | strain: LA116, MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 220 | T>S | strain: LA116, MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 235 | R>M | strain: MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 245 | A>T | strain: LA116, MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 256 | D>N | strain: MW44 [UniProt] | No | ||
| 267 | G>R | strain: MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 278 | I>V | strain: LA108 and LA120 [UniProt] | No | ||
| 309 | Q>E | strain: LA116, LA25, LA4, MA24, MA45, MA50, MW37, MW6 and MW9 [UniProt] | No | ||
| 313 | F>S | strain: NC16a [UniProt] | No | ||
| 341 | R>S | strain: LA116 [UniProt] | No | ||
| 354 | L>I | strain: NC52a, NC73a and NC79b [UniProt] | No | ||
| 387 | V>M | strain: LA9 [UniProt] | No |
No associated diseases with P81910
No regional properties for P81910
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P81910 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| dendrite | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. |
| dendrite membrane | The portion of the plasma membrane surrounding a dendrite. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| odorant binding | Binding to an odorant, any substance capable of stimulating the sense of smell. |
| olfactory receptor activity | Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell. |
| transmembrane signaling receptor activity | Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| detection of chemical stimulus involved in sensory perception of smell | The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal. |
| sensory perception of smell | The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
4 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q9VHE6 | Or85f | Odorant receptor 85f | Drosophila melanogaster (Fruit fly) | PR |
| Q9VHQ6 | Or85c | Odorant receptor 85c | Drosophila melanogaster (Fruit fly) | PR |
| Q9VT20 | Or67b | Odorant receptor 67b | Drosophila melanogaster (Fruit fly) | PR |
| Q9W1P7 | Or59c | Putative odorant receptor 59c | Drosophila melanogaster (Fruit fly) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLSQFFPHIK | EKPLSERVKS | RDAFVYLDRV | MWSFGWTVPE | NKRWDLHYKL | WSTFVTLLIF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ILLPISVSVE | YIQRFKTFSA | GEFLSSIQIG | VNMYGSSFKS | YLTMMGYKKR | QEAKMSLDEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DKRCVCDEER | TIVHRHVALG | NFCYIFYHIA | YTSFLISNFL | SFIMKRIHAW | RMYFPYVDPE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KQFYISSIAE | VILRGWAVFM | DLCTDVCPLI | SMVIARCHIT | LLKQRLRNLR | SEPGRTEDEY |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LKELADCVRD | HRLILDYVDA | LRSVFSGTIF | VQFLLIGIVL | GLSMINIMFF | STLSTGVAVV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LFMSCVSMQT | FPFCYLCNMI | MDDCQEMADS | LFQSDWTSAD | RRYKSTLVYF | LHNLQQPIIL |
| 370 | 380 | 390 | |||
| TAGGVFPISM | QTNLNMVKLA | FTVVTIVKQF | NLAEKFQ |