P80522
Gene name |
porB |
Protein name |
Pyruvate synthase subunit PorB |
Names |
Pyruvate oxidoreductase beta chain, POR, Pyruvic-ferredoxin oxidoreductase subunit beta |
Species |
Methanosarcina barkeri (strain Fusaro / DSM 804) |
KEGG Pathway |
mba:Mbar_A0999 |
EC number |
1.2.7.1: With an iron-sulfur protein as acceptor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P80522
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P80522-F1 | Predicted | AlphaFoldDB |
No variants for P80522
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P80522 | |||||
No associated diseases with P80522
1 regional properties for P80522
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Thiamine pyrophosphate enzyme, TPP-binding | 43 - 205 | IPR011766 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.2.7.1 | With an iron-sulfur protein as acceptor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| 4 iron, 4 sulfur cluster binding | Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. |
| metal ion binding | Binding to a metal ion. |
| pyruvate synthase activity | Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+. |
| thiamine pyrophosphate binding | Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSKTAPKTYI | TSGHSGCAGC | CDAFAAKFTL | MGAGPNTIVI | NPTGCLEVMS | TPFPYSSWQV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PWIHSLFENA | GAVASGVEAA | LKALGKKDDV | KVVSIGGDGS | TMDIGLGALS | GAFERGHDFT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YVCMDNEAYM | NTGVQRSSGT | PFDASTTTTP | AGKVSFGNPR | PKKNMPAIMA | AHGSPYVATT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SIGFPRDMIR | KVKKATEIVG | PTYIHAQAPC | PTGWGFDTSK | TLEIAKLAVE | TCLWPMYEME |
| 250 | 260 | 270 | 280 | 290 | |
| NGEITQVRKV | KNPRPVEEYL | RAQKRFKHLF | TMEGGEEEIK | KIQAIADWNI | KHFELQ |