P80235

PR
Gene name
YAT1 (YAR035W)
Protein name
Putative mitochondrial carnitine O-acetyltransferase
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YAR035W
EC number
2.3.1.7: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

622-687 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P80235

Entry ID Method Resolution Chain Position Source
AF-P80235-F1 Predicted AlphaFoldDB

9 variants for P80235

Variant ID(s) Position Change Description Diseaes Association Provenance
s01-190571 129 T>A No SGRP
s01-190874 230 S>T No SGRP
s01-191060 292 E>K No SGRP
s01-191466 427 R>H No SGRP
s01-191691 502 G>A No SGRP
s01-192035 617 V>I No SGRP
s01-192143 653 A>T No SGRP
s01-192164 660 T>A No SGRP
s01-192176 664 A>T No SGRP

No associated diseases with P80235

1 regional properties for P80235

Type Name Position InterPro Accession
domain Choline/carnitine acyltransferase domain 7 - 636 IPR039551

Functions

Description
EC Number 2.3.1.7 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
carnitine O-acetyltransferase activity Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA.
carnitine O-palmitoyltransferase activity Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine.

2 GO annotations of biological process

Name Definition
carnitine metabolic process The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPNLKRLPIP PLQDTLNRYL ARVEPLQDER QNRRTRRTVL SAENLDALNT LHERLLEYDA
70 80 90 100 110 120
RLAESNPESS YIEQFWYDAY LLYDATVVLN VNPYFQLQDD PTIKDTPETA AQGPYGAHTV
130 140 150 160 170 180
QVRRAARLTT SILKFIRQIR HGTLRTDTVR GKTPLSMDQY ERLFGSSRIP PGPGEPSCHL
190 200 210 220 230 240
QTDATSHHVV AMYRGQFYWF DVLDTRNEPI FATPEQLEWN LYSIIMDAES AGSGSAPFGV
250 260 270 280 290 300
FTTESRRVWS NIRDYLFHAD DCTNWRNLKL IDSALFVVCL DDVAFAADQQ DELTRSMLCG
310 320 330 340 350 360
TSTINLDPHQ HQPPLNVQTG TCLNRWYDKL QLIVTKNGKA GINFEHTGVD GHTVLRLATD
370 380 390 400 410 420
IYTDSILSFA RGVTKNVVDI FSDDDGKPSS SSLASAAHSA NLITIPRKLE WRTDNFLQSS
430 440 450 460 470 480
LHFAETRISD LISQYEFVNL DFSNYGASHI KTVFKCSPDA FVQQVFQVAY FALYGRFETV
490 500 510 520 530 540
YEPAMTKAFQ NGRTEAIRSV TGQSKLFVKS LLDQDASDAT KIQLLHDACT AHSQITRECS
550 560 570 580 590 600
QGLGQDRHLY ALYCLWNQWY KDKLELPPIF RDKSWTTMQN NVLSTSNCGN PCLKSFGFGP
610 620 630 640 650 660
VTANGFGIGY IIRDHSVSVV VSSRHRQTAR FASLMEKSLL EIDRIFKRQQ ARAAKPAART
670 680
TASANTKSED MKYLLSGYDY FDVSVSG