AiPD: Autoinhibited Protein Database

P80217

Gene name	IFI35
Protein name	Interferon-induced 35 kDa protein
Names	IFP 35, Ifi-35
Species	Homo sapiens (Human)
KEGG Pathway	hsa:3430
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-69 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-69 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

1 structures for P80217

Entry ID	Method	Resolution	Chain	Position	Source
AF-P80217-F1	Predicted				AlphaFoldDB

283 variants for P80217

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
CA399677539 rs1405141914	2	S>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs1310890731 CA399677544	3	A>D		No	ClinGen gnomAD
CA399677541 rs1394033786	3	A>T		No	ClinGen gnomAD
rs149119295 CA8589054	4	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8589055 rs138234610	4	P>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA399677556 rs1269604750	5	L>P		No	ClinGen gnomAD
CA290832099 rs977580584	6	D>G		No	ClinGen Ensembl
TCGA novel	7	A>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8589056 rs568883512	7	A>V		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8589076 rs763054365	8	A>T		No	ClinGen ExAC TOPMed gnomAD
rs1204230170 CA399677791	8	A>V		No	ClinGen gnomAD
rs1490705365 CA399677802	10	H>R		No	ClinGen gnomAD
rs149614000 CA290835389	11	A>T		No	ClinGen ESP
rs867092661 CA290835411	12	L>I		No	ClinGen Ensembl
CA290835416 rs899694270	13	Q>*		No	ClinGen TOPMed
CA399677828 rs1431307668	14	E>K		No	ClinGen gnomAD
CA399677831 rs1178978275	14	E>V		No	ClinGen TOPMed gnomAD
CA8589079 rs12948870	16	Q>E		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs148786311 CA8589080	18	R>G		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399677898 rs1158317108	20	K>T		No	ClinGen gnomAD
CA290835453 rs770588017	21	M>K		No	ClinGen Ensembl
CA290835457 rs866917158	23	L>M		No	ClinGen Ensembl
rs1358815892 CA399677940	24	W>R		No	ClinGen gnomAD
rs142458559 CA8589081	25	D>N		No	ClinGen ESP ExAC TOPMed gnomAD
rs367701448 CA8589083	27	Q>*		No	ClinGen ESP ExAC gnomAD
CA290835500 rs867438277	29	L>M		No	ClinGen gnomAD
rs1597779746 CA399678016	31	K>*		No	ClinGen Ensembl
CA399678023 COSM1383491 rs748648651 CA8589084	31	K>N	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC gnomAD NCI-TCGA
CA399678035 rs1361084601	32	E>D		No	ClinGen gnomAD
CA8589085 rs758942957	32	E>G		No	ClinGen ExAC TOPMed gnomAD
rs1222595930 CA399678046	33	L>P		No	ClinGen TOPMed gnomAD
CA399678049 rs777691679 CA8589088	34	G>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC TOPMed gnomAD NCI-TCGA
CA8589089 rs747130156	35	D>Y		No	ClinGen ExAC TOPMed gnomAD
rs776914024 CA8589091	37	P>S		No	ClinGen ExAC gnomAD
CA399678089 rs1378702889	38	K>E		No	ClinGen gnomAD
rs1263388351 CA399678713	44	S>P		No	ClinGen gnomAD
rs1338270412 CA399678737	45	V>G		No	ClinGen TOPMed gnomAD
CA290836180 rs370391721	47	K>R		No	ClinGen ESP TOPMed gnomAD
rs1191762352 CA399678816	51	V>A		No	ClinGen TOPMed
rs1295751208 CA399678806	51	V>I		No	ClinGen gnomAD
rs1295751208 CA399678810	51	V>L		No	ClinGen gnomAD
CA8589116 rs768412142	53	R>*		No	ClinGen ExAC TOPMed gnomAD
rs780267427 CA290836189	53	R>Q		No	ClinGen TOPMed gnomAD
CA399678855 rs1485204949	54	G>E		No	ClinGen TOPMed
rs1230369734 CA399678892	58	Q>K		No	ClinGen TOPMed
rs774360258 CA8589117	59	D>G		No	ClinGen ExAC gnomAD
CA399678904 rs1461626278	59	D>N		No	ClinGen TOPMed gnomAD
rs200866570 CA8589118	60	P>A		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8589119 rs771605420	60	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs200866570 CA290836196	60	P>S		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1036850660 CA290836206	62	V>A		No	ClinGen TOPMed gnomAD
rs1308951342 CA399678951	63	P>R		No	ClinGen TOPMed
rs760298021 CA399678965	64	K>N		No	ClinGen ExAC TOPMed gnomAD
rs1597780479 CA399678961	64	K>R		No	ClinGen Ensembl
CA8589122 rs368042561	66	L>S		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399679021 rs1597780493	69	N>S		No	ClinGen Ensembl
TCGA novel	70	L>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8589124 rs763377602	71	R>Q		No	ClinGen ExAC gnomAD
CA8589123 rs139469566	71	R>W		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8589125 rs145061445	72	I>M		No	ClinGen ESP ExAC TOPMed gnomAD
CA399679066 rs1460713614	74	C>R		No	ClinGen gnomAD
rs752091266 CA8589126	74	C>Y		No	ClinGen ExAC TOPMed gnomAD
rs1597780523 CA399679083	75	P>L		No	ClinGen Ensembl
rs1567743709 CA399679090	76	L>P		No	ClinGen Ensembl
CA399679110 rs141921308	78	A>E		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA399679108 rs141921308	78	A>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8589128 rs141921308 COSM269347	78	A>V	large_intestine [Cosmic]	No	ClinGen cosmic curated 1000Genomes ExAC TOPMed gnomAD
CA290836299 rs958627925	79	G>V		No	ClinGen gnomAD
TCGA novel	80	S>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs780428452 CA8589131	83	I>T		No	ClinGen ExAC gnomAD
rs1301866217 CA399679177	85	F>S		No	ClinGen gnomAD
CA919844207 rs1567743696	85	F>S		No	ClinGen Ensembl
rs749034220 CA8589132	87	D>N		No	ClinGen ExAC gnomAD
rs768485533 CA8589133	89	K>T		No	ClinGen ExAC TOPMed gnomAD
rs1272982982 CA399679277	92	E>D		No	ClinGen gnomAD
rs1375314395 CA399679279	93	Q>E		No	ClinGen gnomAD
rs1287039281 CA399679283	93	Q>H		No	ClinGen gnomAD
rs759166671 CA8589144	93	Q>P		No	ClinGen ExAC gnomAD
CA399679290 rs1597780656	94	V>G		No	ClinGen Ensembl
TCGA novel	98	K>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs976936685 CA399679321	99	E>*		No	ClinGen TOPMed gnomAD
rs976936685 CA290836474	99	E>K		No	ClinGen TOPMed gnomAD
rs1294115089 CA399679324	99	E>V		No	ClinGen gnomAD
rs1452229060 CA399679336	101	T>A		No	ClinGen gnomAD
rs374815335 CA8589146	101	T>K		No	ClinGen ESP ExAC TOPMed gnomAD
CA8589145 COSM3691593 rs374815335	101	T>M	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA399679335 rs1452229060	101	T>P		No	ClinGen gnomAD
rs374815335 CA8589147	101	T>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8589149 rs750468739	102	I>N		No	ClinGen ExAC
TCGA novel	103	N>D	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8589151 rs766627219	104	M>V		No	ClinGen ExAC gnomAD
CA399679361 rs1379305891	105	E>Q		No	ClinGen gnomAD
rs1417549605 CA399679369	106	E>Q		No	ClinGen gnomAD
CA8589152 rs754088504	107	C>R		No	ClinGen ExAC TOPMed
rs755193476 CA8589153	107	C>Y		No	ClinGen ExAC gnomAD
rs201830704 CA8589154	108	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8589155 rs747914826	108	R>L		No	ClinGen ExAC TOPMed gnomAD
CA8589156 rs747914826	108	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs201830704 CA290836530	108	R>W		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8589160 rs376682517	110	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen 1000Genomes ESP ExAC NCI-TCGA TOPMed gnomAD
COSM1210256 rs746463710 CA8589159	110	R>W	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
rs1597780749 CA399679396	111	V>G		No	ClinGen Ensembl
CA399679403 rs1334338311	112	Q>H		No	ClinGen TOPMed
CA8589161 rs745513010	112	Q>R		No	ClinGen ExAC gnomAD
rs1597780766 CA399679409	113	V>G		No	ClinGen Ensembl
CA399679415 rs1317384276	114	Q>R		No	ClinGen gnomAD
CA399679423 rs1357176258	115	P>T		No	ClinGen gnomAD
rs1209264414 CA399679449	117	E>G		No	ClinGen gnomAD
CA8589164 rs774738003	120	M>T		No	ClinGen ExAC gnomAD
rs769354659 CA8589163	120	M>V		No	ClinGen ExAC TOPMed gnomAD
rs1223120119 CA399679489	121	V>D		No	ClinGen TOPMed gnomAD
rs762089420 CA8589165	121	V>F		No	ClinGen ExAC TOPMed gnomAD
rs1041538049 CA290836592	123	T>N		No	ClinGen Ensembl
CA8589166 rs768083989	123	T>P		No	ClinGen ExAC gnomAD
rs1185092955 CA399679511	124	I>T		No	ClinGen TOPMed gnomAD
CA399679518 rs1333270839	125	Q>*		No	ClinGen TOPMed
CA8589167 rs147582201	125	Q>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1421326125 CA399679580	126	M>I		No	ClinGen gnomAD
CA399679574 rs588703 CA399679572	126	M>L		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA290836855 rs904640323	126	M>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs588703 VAR_063758 VAR_082872 CA8589186	126	M>V		No	ClinGen UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs776729572 CA8589187	127	S>A		No	ClinGen ExAC gnomAD
rs759535040 CA8589188	128	S>N		No	ClinGen ExAC gnomAD
CA399679599 rs1401228109	128	S>R		No	ClinGen gnomAD
CA8589189 rs765440953	129	Q>*		No	ClinGen ExAC gnomAD
CA8589190 rs752849055	129	Q>H		No	ClinGen ExAC TOPMed gnomAD
rs1002597752 CA290836866	132	G>R		No	ClinGen Ensembl
rs763844158 CA8589192 COSM1210257	133	R>Q	large_intestine [Cosmic]	No	ClinGen cosmic curated ExAC TOPMed gnomAD
CA8589191 rs149709197	133	R>W		No	ClinGen ESP ExAC TOPMed gnomAD
rs1597781007 CA399679647	134	R>G		No	ClinGen Ensembl
CA399679650 rs1567744053	134	R>K		No	ClinGen Ensembl
CA399679665 rs1278145763	135	V>G		No	ClinGen gnomAD
CA8589195 rs757148523	136	L>S		No	ClinGen ExAC gnomAD
rs1344739643 CA399679681	137	V>F		No	ClinGen gnomAD
CA399679684 rs1597781037	137	V>G		No	ClinGen Ensembl
CA399679696 rs1567744079	138	T>I		No	ClinGen Ensembl
rs1244782411 CA399679727	142	A>T		No	ClinGen gnomAD
rs1198410498 CA399679749	144	L>F		No	ClinGen gnomAD
CA8589196 rs780997177	144	L>P		No	ClinGen ExAC TOPMed gnomAD
rs749891046 CA8589197	145	R>S		No	ClinGen ExAC gnomAD
CA399679781 rs1567744105	147	S>R		No	ClinGen Ensembl
CA290836935 rs1021825359	148	E>K		No	ClinGen Ensembl
rs968901082 CA290836943	150	E>D		No	ClinGen Ensembl
CA399679811 rs1192224414	150	E>Q		No	ClinGen gnomAD
rs1260942379 CA399679814	150	E>V		No	ClinGen gnomAD
rs779686162 CA399679832	152	L>P		No	ClinGen ExAC TOPMed gnomAD
rs779686162 CA8589200	152	L>R		No	ClinGen ExAC TOPMed gnomAD
rs377676655 CA8589202	153	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
CA8589201 rs748921534	153	D>G		No	ClinGen ExAC gnomAD
rs747405142 CA8589204	156	E>D		No	ClinGen ExAC gnomAD
rs924751797 CA290836967	157	I>F		No	ClinGen TOPMed
rs145567403 CA8589205	157	I>T		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs769757979 CA399679882 CA8589208	158	F>L		No	ClinGen ExAC TOPMed gnomAD
rs777017425 CA8589206	158	F>L		No	ClinGen ExAC gnomAD
CA8589207 rs760145503	158	F>Y		No	ClinGen ExAC TOPMed gnomAD
CA8589209 rs369559189	159	F>L		No	ClinGen ESP ExAC gnomAD
CA8589210 rs763115088	159	F>S		No	ClinGen ExAC gnomAD
rs909534000 CA290836999	160	G>S		No	ClinGen TOPMed gnomAD
CA290837003 rs961121303	162	T>P		No	ClinGen TOPMed
CA399679920 rs1215435767	162	T>S		No	ClinGen gnomAD
rs1283331467 CA399679935	163	R>S		No	ClinGen TOPMed gnomAD
rs202144105 CA8589213	165	G>R		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA8589214 rs767407648	166	G>D		No	ClinGen ExAC TOPMed gnomAD
rs1262704928 CA399679971	166	G>R		No	ClinGen gnomAD
CA8589215 rs750326884	167	G>S		No	ClinGen ExAC TOPMed gnomAD
rs370544876 CA399680002	168	D>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs145578882 CA399679994	168	D>H		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs145578882 CA8589217	168	D>N		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
CA399679991 rs145578882	168	D>Y		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1567744197 CA399680017	170	D>Y		No	ClinGen Ensembl
COSM1254604 rs140488187 CA8589220	171	V>I	oesophagus [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
CA8589222 rs369228705	172	R>G		No	ClinGen ExAC TOPMed gnomAD
rs150695787 RCV000950265 CA8589223	172	R>Q		No	ClinGen ClinVar 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
CA8589221 rs369228705	172	R>W		No	ClinGen ExAC TOPMed gnomAD
rs770379286 CA8589225	174	L>P		No	ClinGen ExAC gnomAD
rs199510319 CA8589231	180	M>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs768809782 CA8589230	180	M>T		No	ClinGen ExAC gnomAD
rs762166248 CA8589232	182	G>R		No	ClinGen ExAC gnomAD
rs564028702 CA8589233	184	A>T		No	ClinGen 1000Genomes ExAC gnomAD
CA8589235 rs374153933	187	G>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs1457139369 CA399680287	187	G>R		No	ClinGen gnomAD
CA8589236 rs141896991	188	V>M		No	ClinGen ESP ExAC TOPMed
CA8589259 rs752302821	190	Q>*		No	ClinGen ExAC gnomAD
rs201614442 CA8589260	191	R>C		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA8589261 COSM215690 rs146311145	191	R>H	central_nervous_system [Cosmic]	No	ClinGen cosmic curated 1000Genomes ESP ExAC TOPMed gnomAD
rs372379979 CA8589262	193	C>F		No	ClinGen ESP ExAC gnomAD
rs780464597 CA8589264	194	Q>L		No	ClinGen ExAC gnomAD
rs755531972 CA8589266	196	G>S		No	ClinGen ExAC TOPMed gnomAD
rs1160438703 CA399680468	197	Q>*		No	ClinGen TOPMed gnomAD
CA399680539 rs1195864462	201	P>L		No	ClinGen gnomAD
rs1264537639 CA399680550	203	G>S		No	ClinGen gnomAD
rs1192116527 CA399680570	204	G>E		No	ClinGen gnomAD
rs1427762301 CA399680588	205	Q>H		No	ClinGen gnomAD
rs748294501 CA8589268	206	Q>*		No	ClinGen ExAC gnomAD
rs748294501 CA399680593	206	Q>E		No	ClinGen ExAC gnomAD
rs1313075664 CA399680618	207	V>A		No	ClinGen Ensembl
CA399680648 rs1597781492	210	R>G		No	ClinGen Ensembl
rs550567872 CA8589271	210	R>K		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs550567872 CA8589270	210	R>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1312606222 CA399680664	211	V>D		No	ClinGen TOPMed
CA399680676 rs1305496854	212	S>F		No	ClinGen TOPMed
CA8589272 rs200811245	213	P>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ESP ExAC NCI-TCGA TOPMed gnomAD
rs200811245 CA399680687	213	P>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA8589275 rs769873611	214	Y>H		No	ClinGen ExAC TOPMed gnomAD
rs1013052001 CA290837370	215	V>M		No	ClinGen Ensembl
rs13229 CA8589277	216	N>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1278204829 CA399680748	217	G>E		No	ClinGen gnomAD
rs1218377147 CA399680743	217	G>R		No	ClinGen gnomAD
CA8589278 rs763570551	218	E>K		No	ClinGen ExAC gnomAD
CA399680805 rs998516333	221	K>R		No	ClinGen gnomAD
rs998516333 CA290837395	221	K>T		No	ClinGen gnomAD
CA290837399 rs761497733	222	A>S		No	ClinGen ExAC TOPMed gnomAD
rs761497733 CA8589280	222	A>T		No	ClinGen ExAC TOPMed gnomAD
rs934065641 CA290837410	223	E>D		No	ClinGen TOPMed gnomAD
rs1444820347 CA399680903	224	I>M		No	ClinGen TOPMed
rs764211735 CA8589306	226	S>*		No	ClinGen ExAC TOPMed gnomAD
CA8589305 rs764211735	226	S>L		No	ClinGen ExAC TOPMed gnomAD
rs764211735 CA399680921	226	S>W		No	ClinGen ExAC TOPMed gnomAD
CA399680932 rs1440979116	227	Q>R		No	ClinGen TOPMed
CA8589308 rs781579279	228	P>Q		No	ClinGen ExAC gnomAD
rs1460552450 CA399680951	229	V>D		No	ClinGen TOPMed
CA8589309 rs746151762	229	V>F		No	ClinGen ExAC TOPMed gnomAD
CA8589310 rs755969340	231	R>C		No	ClinGen ExAC TOPMed gnomAD
rs941550865 CA290837759	231	R>H	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs376408544 CA290837760	232	S>*		No	ClinGen ESP ExAC TOPMed gnomAD
rs376408544 CA8589311	232	S>L		No	ClinGen ESP ExAC TOPMed gnomAD
CA8589314 rs773873458	233	V>I		No	ClinGen ExAC TOPMed gnomAD
rs1389937216 CA399680988	234	L>P		No	ClinGen gnomAD
CA8589315 rs747665468	235	V>A		No	ClinGen ExAC gnomAD
CA8589317 rs143278077	236	L>F		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1342859075 CA399681047	238	I>T		No	ClinGen gnomAD
CA399681056 rs765602573	239	P>L		No	ClinGen ExAC gnomAD
CA8589320 rs765602573	239	P>R		No	ClinGen ExAC gnomAD
rs376575632 CA399681066	240	D>A		No	ClinGen ESP gnomAD
rs376575632 CA290837788	240	D>G		No	ClinGen ESP gnomAD
CA290837799 rs376575632	240	D>V		No	ClinGen ESP gnomAD
rs1012015674 CA290837785	240	D>Y		No	ClinGen TOPMed gnomAD
CA399681093 rs1278845476	242	L>S		No	ClinGen gnomAD
CA8589323 rs201486546	245	P>L		No	ClinGen ExAC TOPMed gnomAD
CA8589322 rs763467879	245	P>S		No	ClinGen ExAC gnomAD
TCGA novel	246	E>A	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA8589318 rs773024475	246	E>H		No	ClinGen ExAC gnomAD
CA399681170 rs1323246396	247	L>P		No	ClinGen TOPMed
rs1478138073 CA399681187	248	H>R		No	ClinGen TOPMed gnomAD
CA399681215 rs751620948 CA8589325	249	D>E		No	ClinGen ExAC TOPMed gnomAD
rs140218345 CA8589326	250	V>I		No	ClinGen ESP ExAC TOPMed gnomAD
CA399681231 rs1467352458	251	L>P		No	ClinGen gnomAD
CA8589327 rs767774874	253	I>V		No	ClinGen ExAC gnomAD
CA8589328 rs750642778	254	H>N		No	ClinGen ExAC gnomAD
CA399681363 rs756341282	260	R>C		No	ClinGen ExAC TOPMed gnomAD
CA8589330 rs561841119	260	R>H		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs756341282 CA8589329	260	R>S		No	ClinGen ExAC TOPMed gnomAD
rs749072575 CA8589335	261	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs754880852 CA8589336	262	G>D		No	ClinGen ExAC gnomAD
rs778732814 CA8589339	263	G>R		No	ClinGen ExAC TOPMed gnomAD
CA399681404 rs1235823515	264	E>*		No	ClinGen gnomAD
CA8589340 rs748139594	265	V>A		No	ClinGen ExAC gnomAD
rs748139594 CA399681425	265	V>G		No	ClinGen ExAC gnomAD
rs1275089790 CA399681417 COSM1383494	265	V>L	large_intestine [Cosmic]	No	ClinGen cosmic curated gnomAD
rs1048299 CA8589342	266	E>K		No	ClinGen ExAC gnomAD
rs746639337 CA8589343	267	A>T		No	ClinGen ExAC gnomAD
CA8589346 rs763230372	268	L>P		No	ClinGen ExAC gnomAD
rs775882822 CA399681460	268	L>V		No	ClinGen ExAC gnomAD
rs764579489 CA8589347	269	T>I		No	ClinGen ExAC gnomAD
rs764579489 CA8589348	269	T>R		No	ClinGen ExAC gnomAD
rs767684956 CA8589350	270	V>A		No	ClinGen ExAC gnomAD
CA8589349 rs762451969	270	V>F		No	ClinGen ExAC TOPMed gnomAD
CA399681475 rs762451969	270	V>L		No	ClinGen ExAC TOPMed gnomAD
CA8589352 COSM3402918 rs375429330	271	V>I	Variant assessed as Somatic; 0.0 impact. central_nervous_system [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA TOPMed gnomAD
CA399681517 rs1288822870	273	Q>*		No	ClinGen gnomAD
CA8589355 rs148626513	274	G>R		No	ClinGen ESP ExAC TOPMed gnomAD
CA399681568 rs1388896310	276	Q>E		No	ClinGen gnomAD
CA399681574 rs142126580	276	Q>H		No	ClinGen ESP ExAC TOPMed
rs1324704067 CA399681571	276	Q>R		No	ClinGen gnomAD
CA8589357 rs752596965	277	G>D		No	ClinGen ExAC gnomAD
rs201858273 CA8589358	279	A>P		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs201858273 CA399681611	279	A>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA399681620 rs1310943236	280	V>L		No	ClinGen gnomAD
rs1048323 CA290837970	283	S>F		No	ClinGen Ensembl
rs1238715832 CA399681671	283	S>P		No	ClinGen gnomAD
CA8589360 rs777215135	284	E>G		No	ClinGen ExAC gnomAD
rs1489461242 CA399681709	286	G>S		No	ClinGen gnomAD
rs1313194825 CA399681731	287	G>W		No	ClinGen TOPMed

No associated diseases with P80217

3 regional properties for P80217

Type	Name	Position	InterPro Accession
domain	Nmi/IFP 35 domain	81 - 170	IPR009909-1
domain	Nmi/IFP 35 domain	180 - 267	IPR009909-2
domain	Nmi/IFP 35 domain, N-terminal	9 - 80	IPR009938

Functions

		Description
EC Number
Subcellular Localization	Cytoplasm Nucleus Secreted	Cytoplasmic IFI35 localizes in punctate granular structures (PubMed:10950963) Nuclear localization increased is stimulated by IFN-alpha (PubMed:10950963, PubMed:8288566) Extracelullar following secretion by macrophage (PubMed:29038465)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

5 GO annotations of cellular component

Name	Definition
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extracellular space	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
nucleus	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name	Definition
identical protein binding	Binding to an identical protein or proteins.

8 GO annotations of biological process

Name	Definition
innate immune response	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
macrophage activation involved in immune response	A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
negative regulation of cell population proliferation	Any process that stops, prevents or reduces the rate or extent of cell proliferation.
negative regulation of NIK/NF-kappaB signaling	Any process that stops, prevents or reduces the frequency, rate or extent of NIK/NF-kappaB signaling.
positive regulation of inflammatory response	Any process that activates or increases the frequency, rate or extent of the inflammatory response.
positive regulation of innate immune response	Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
positive regulation of NIK/NF-kappaB signaling	Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
positive regulation of toll-like receptor 4 signaling pathway	Any process that activates or increases the frequency, rate, or extent of toll-like receptor 4 signaling pathway.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
O35309	Nmi	N-myc-interactor	Mus musculus (Mouse)	PR

10	20	30	40	50	60
MSAPLDAALH	ALQEEQARLK	MRLWDLQQLR	KELGDSPKDK	VPFSVPKIPL	VFRGHTQQDP
70	80	90	100	110	120
EVPKSLVSNL	RIHCPLLAGS	ALITFDDPKV	AEQVLQQKEH	TINMEECRLR	VQVQPLELPM
130	140	150	160	170	180
VTTIQMSSQL	SGRRVLVTGF	PASLRLSEEE	LLDKLEIFFG	KTRNGGGDVD	VRELLPGSVM
190	200	210	220	230	240
LGFARDGVAQ	RLCQIGQFTV	PLGGQQVPLR	VSPYVNGEIQ	KAEIRSQPVP	RSVLVLNIPD
250	260	270	280
ILDGPELHDV	LEIHFQKPTR	GGGEVEALTV	VPQGQQGLAV	FTSESG