P79750

PR
Gene name
csf1r1
Protein name
Macrophage colony-stimulating factor 1 receptor 1
Names
CSF-1-R 1
Species
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

903-975 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

799-824 (Activation loop from InterPro)

Target domain

584-918 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for P79750

Entry ID Method Resolution Chain Position Source
AF-P79750-F1 Predicted AlphaFoldDB

No variants for P79750

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P79750

No associated diseases with P79750

13 regional properties for P79750

Type Name Position InterPro Accession
domain Protein kinase domain 584 - 918 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 584 - 913 IPR001245
conserved_site Tyrosine-protein kinase, receptor class III, conserved site 644 - 657 IPR001824
domain Immunoglobulin subtype 2 227 - 299 IPR003598
domain Immunoglobulin subtype 34 - 113 IPR003599-1
domain Immunoglobulin subtype 125 - 208 IPR003599-2
domain Immunoglobulin subtype 221 - 310 IPR003599-3
domain Immunoglobulin subtype 329 - 407 IPR003599-4
domain Immunoglobulin-like domain 215 - 308 IPR007110-1
domain Immunoglobulin-like domain 419 - 513 IPR007110-2
active_site Tyrosine-protein kinase, active site 778 - 790 IPR008266
binding_site Protein kinase, ATP binding site 590 - 619 IPR017441
domain Tyrosine-protein kinase, catalytic domain 584 - 914 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • The autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
cytokine binding Binding to a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity.
transmembrane receptor protein tyrosine kinase activity Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.

4 GO annotations of biological process

Name Definition
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
inflammatory response The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
innate immune response Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
transmembrane receptor protein tyrosine kinase signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQSFLPLLMG IMASASSVEW RHPVIWFNSK VVQSSEVVVK PGTSLELKCG GDGPVNWQTR
70 80 90 100 110 120
LPKHKRYMSR SPGNLRTIRV ARPTAEFTGT YKCFYSAWAQ HRHLTSSVHV YVKDPNRVFW
130 140 150 160 170 180
TSSTSLRVVR KEGEDYLLPC LLTDPEATDL GLRMDNGTTV PPEMNYTVYR HRGILIRSLQ
190 200 210 220 230 240
PSFNADYVCT AKVKGVEKTS KTFSINVIQK LRFPPYVFLE MDEYVRIVGE ELQIRCMTHN
250 260 270 280 290 300
PNFNYNVTWN YTTKSRVTIE ERVRSSGENR LDIQSILTIS AVDLADTGNI SCIGTNEAGV
310 320 330 340 350 360
NSSNTYLLVV EKPYIRLWPQ LIPKLASQGL SVEVNEGEDL ELGVMVEAYP QITDHRWHTP
370 380 390 400 410 420
TSPSTSMQEH IYHARLQLKR MNAQEQGQYT FYAKSNLANG SISFHVKMYQ KPIAVVRWEN
430 440 450 460 470 480
ITTLTCTSFG YPAPQIIWYQ CSGIRPTCNG NNTGLPKQNH PQALTVEVQR EEYGAVEVES
490 500 510 520 530 540
VFTVGLSNHR MTVECVAFNL VGVSSDTFTV EVSDKLFTST LIGAAGVLAI FLLLLVFLLY
550 560 570 580 590 600
KYKQKPRFEI RWKIIEAREG NNYTFIDPTQ LPYNEKWEFP RDKLKLGKVL GAGAFGKVVE
610 620 630 640 650 660
ATAFGLGEDK DNTLRVAVKM LKANAHSDER EALMSELKIL SHLGHHQNIV NLLGACTYGG
670 680 690 700 710 720
PVLVITEYCS LGDLLNFLRQ KAETFVNLVM NIPEIMENSN DYKNICNQKW YIRSDSGISS
730 740 750 760 770 780
TSSSTYLEMR PSQQSHIEAS GRKSLCEDNG DWPLDIDDLL RFSLQVAQGL DFLASRNCIH
790 800 810 820 830 840
RDVAARNVLL TDKRVAKICD FGLARDIMND SNYVVKGNAR LPVKWMAPES IFDCVYTVQS
850 860 870 880 890 900
DVWSYGILLW EIFSLGKSPY PSMAVDSRFY KMVKRGYQMS QPDFALPEIY MIMKMCWNLE
910 920 930 940 950 960
PTERPTFSMI SQMINRLLGG QDEQEKLIYR NVQPEQVAEG EACDEPKRYD PPCERSCDHE
970
EEEEPLMKTN NYQFC