P79749

PR
Gene name
pdgfrb
Protein name
Platelet-derived growth factor receptor beta
Names
PDGF-R-beta, PDGFR-beta, Beta platelet-derived growth factor receptor, Beta-type platelet-derived growth factor receptor
Species
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KEGG Pathway
EC number
2.7.10.1: Protein-tyrosine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-52 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P79749

Entry ID Method Resolution Chain Position Source
AF-P79749-F1 Predicted AlphaFoldDB

No variants for P79749

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P79749

No associated diseases with P79749

13 regional properties for P79749

Type Name Position InterPro Accession
domain Protein kinase domain 596 - 957 IPR000719
domain Serine-threonine/tyrosine-protein kinase, catalytic domain 597 - 952 IPR001245
domain Immunoglobulin subtype 2 231 - 300 IPR003598-1
domain Immunoglobulin subtype 2 331 - 401 IPR003598-2
domain Immunoglobulin subtype 37 - 124 IPR003599-1
domain Immunoglobulin subtype 225 - 313 IPR003599-2
domain Immunoglobulin subtype 325 - 412 IPR003599-3
domain Immunoglobulin-like domain 35 - 109 IPR007110-1
domain Immunoglobulin-like domain 216 - 309 IPR007110-2
active_site Tyrosine-protein kinase, active site 817 - 829 IPR008266
domain Immunoglobulin I-set 323 - 413 IPR013098
binding_site Protein kinase, ATP binding site 602 - 630 IPR017441
domain Tyrosine-protein kinase, catalytic domain 596 - 953 IPR020635

Functions

Description
EC Number 2.7.10.1 Protein-tyrosine kinases
Subcellular Localization
  • Cell membrane ; Single-pass type I membrane protein
  • Cytoplasmic vesicle
  • Lysosome lumen
  • After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
lysosomal lumen The volume enclosed within the lysosomal membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
platelet-derived growth factor beta-receptor activity Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity.

1 GO annotations of biological process

Name Definition
chemotaxis The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLRASAMRAA VLHLTVALAA LLSSCTTVSC LKIVPEEKQL ILAEGSSLSL TCAGSSETTW
70 80 90 100 110 120
DLKSDDVPFF QMKAESSDLN YKIVQSNSTA SVLTLWHVDW KNTAVYQCRE QLTGEIKEVA
130 140 150 160 170 180
VFVPDRFSPQ TLRFIESSHG MVTKTSGEST VPCVVTNPNI TVTLYDKDTD LPVNGVYVPS
190 200 210 220 230 240
EGFKAYLDYR TYVCRGELNG EVKESQAFNV YSIHVPEDID AYVNASQTVL KQGEPLTVNC
250 260 270 280 290 300
TVQGVELVLF SWDIPNRDIV KHKPETVVLS ATTMRSCLVF PHATVAHSGT YVCHAHESTQ
310 320 330 340 350 360
DQKAFASVNI TVLERGFVAV KSTRKQNITA ELQENVELRV EIEAYPPPQI RWKKDGAPVR
370 380 390 400 410 420
GDKTIIIRQE HEIRYVTILT LVRVRTEQKG LYTALITNED DVKEVTFALE VQVLARIKDL
430 440 450 460 470 480
TDHHLPGKKQ LVTCVAEGVP TPTIQWYSCD SMLKCNNQTS LWQQLKADPE LLSIHTSVTE
490 500 510 520 530 540
ARQTNQVRSQ VTFFKPQHTT VRCETTNQEG LIDFRDVKLV SSSLFSQVVL LAVVLTLVPI
550 560 570 580 590 600
IIMSIIILIA VWKKKPRYEI RWKVIESVSQ DGHEYIYVDP IHLPYDLAWE MPRDNLVLGR
610 620 630 640 650 660
TLGSGAFGRV VEATAHGLSH SQSSIKVAVK MLKATARRSE TQALMSELKI MSHLGPHLNI
670 680 690 700 710 720
VNLLAACTKH GPLYLVTEYC RYGDLVDYLH RNKHTFLQYY LDKNQDDGSL ISGGSTPLSQ
730 740 750 760 770 780
RKGYVSFGSE SDGGYMDMSK DEPAVYVPMQ EQMDTIKYAD IQPSPYESPY QQDLYQEQGG
790 800 810 820 830 840
GRVDLVISDS PALTYDDLLG FSYQVAKGME FLASKNCVHR DLAARNVLIC EGKLVKICDF
850 860 870 880 890 900
GLARDIMHDS NYISKGSTFL PLKWMAPESI FHNLYTTLSD VWSYGILLWE IFTLGGTPYP
910 920 930 940 950 960
DLPMNELFYS PLKRGYRMAK PAHASDEVYE IMKRCWDETF EKRPDFSFLV HCVGDMLTDS
970 980 990 1000 1010 1020
YKKKYSQVNE TFLKSDHPAV ARTKPRLSSP FPIANPAFGS PSLVGLSDFP DPYNQNTRRF
1030 1040
RNEAEVQEGV TSFNEYIIPI PDPKPEKS