P79748
Gene name |
htr1d |
Protein name |
5-hydroxytryptamine receptor 1D |
Names |
5-HT-1D, 5-HT1D, 5HT1D, F1D, Serotonin receptor 1D |
Species |
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) |
KEGG Pathway |
tru:101076478 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P79748
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P79748-F1 | Predicted | AlphaFoldDB |
No variants for P79748
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P79748 | |||||
No associated diseases with P79748
No regional properties for P79748
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P79748 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| synapse | The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| G protein-coupled serotonin receptor activity | Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). |
| chemical synaptic transmission | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. |
| regulation of behavior | Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. |
| regulation of locomotion | Any process that modulates the frequency, rate or extent of locomotion of a cell or organism. |
| smooth muscle contraction | A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length. |
| vasoconstriction | A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELDNNSLDY | FSSNFTDIPS | NTTVAHWTEA | TLLGLQISVS | VVLAIVTLAT | MLSNAFVIAT |
| 70 | 80 | 90 | 100 | 110 | 120 |
| IFLTRKLHTP | ANFLIGSLAV | TDMLVSILVM | PISIVYTVSK | TWSLGQIVCD | IWLSSDITFC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TASILHLCVI | ALDRYWAITD | ALEYSKRRTM | RRAAVMVAVV | WVISISISMP | PLFWRQAKAH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| EELKECMVNT | DQISYTLYST | FGAFYVPTVL | LIILYGRIYV | AARSRIFKTP | SYSGKRFTTA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| QLIQTSAGSS | LCSLNSASNQ | EAHLHSGAGG | EGGGSPLFVN | SVKVKLADNV | LERKRLCAAR |
| 310 | 320 | 330 | 340 | 350 | 360 |
| ERKATKTLGI | ILGAFIICWL | PFFVVTLVWA | ICKECSFDPL | LFDVFTWLGY | LNSLINPVIY |
| 370 | |||||
| TVFNDEFKQA | FQKLIKFRR |