P79701
Gene name |
FLT4 (K2, VEGFR3) |
Protein name |
Vascular endothelial growth factor receptor 3 |
Names |
VEGFR-3, Endothelial kinase receptor EK2, Quek 2, Quek2 |
Species |
Coturnix coturnix (Common quail) (Tetrao coturnix) |
KEGG Pathway |
|
EC number |
2.7.10.1: Protein-tyrosine kinases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
1066-1091 (Activation loop from InterPro)
Target domain |
858-1185 (Protein kinase domain) |
Relief mechanism |
|
Assay |
|
Autoinhibited structure
Activated structure
1 structures for P79701
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P79701-F1 | Predicted | AlphaFoldDB |
No variants for P79701
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P79701 | |||||
No associated diseases with P79701
No regional properties for P79701
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P79701 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.10.1 | Protein-tyrosine kinases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| protein homodimerization activity | Binding to an identical protein to form a homodimer. |
| vascular endothelial growth factor receptor activity | Combining with a vascular endothelial growth factor (VEGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| angiogenesis | Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. |
| cell differentiation | The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| protein autophosphorylation | The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation). |
| vascular endothelial growth factor receptor signaling pathway | The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor (VEGFR) on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
| vascular endothelial growth factor signaling pathway | The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKRVCTLPLW | LWLGIVSEAD | LVSSYSMTPP | TLSITEEEHI | INAKDTLTIT | CRGQHPLEWS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WPGARWTPVE | GRRRWNSQPQ | QRPVGAGNPE | EDCEGTGTKP | YCKVLVLTES | QANDTGYYHC |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YYKYIDAKIE | GTTAVSAYIF | VRDFEQPFIN | KPETLLISKK | ENTWVPCLVS | IPDLNVTLIS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QNSLIHPDRK | TIFWDNKKGM | QVPTQLIRDS | LFVQCETVID | NKVFKSNFFI | IHIAGIELYD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IQLYPKKAME | LLVGEKLVLN | CTVWAEFNSG | VRFQWTYPGK | QMQRAVIESE | RRSLQTHTEL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SSILTLHNVS | QQDLGRYTCT | ATNGAQMLEE | STDVIVHEKP | FINVEWRKGP | VIEATAGDEA |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VKLPVKVVAY | PQPDFQWYKA | GKLIPKQSQS | SMQIKDVAEH | HAGTYTLVLR | NRLVGLEKRI |
| 430 | 440 | 450 | 460 | 470 | 480 |
| SLQLIVNVPP | RIHEKETSSP | SIYSRRSPQA | LTCTVYGIPA | PEVIQWQWRP | WMPCRMFSRR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SLNSRHRAAR | RHQRDRMPEC | KDWKDVSRQD | AVNPIESIDT | WVEFVEGRNK | TVSKLAIQEA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| NVSAMYKCIA | SNKVGRDERL | IYFYVTTIPD | GFEIESQPSE | EPIEGQDLQL | SCNADNYTYE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| NLQWYRLNLS | KLHDEEGNPL | VLDCKNVHHY | ATKMQGELRF | QPDSNDATLL | LTIPNISLGE |
| 670 | 680 | 690 | 700 | 710 | 720 |
| EGDYVCEVQN | RKTREKHCHK | KYISVQALEI | PRLKQNLTDI | WVNVSDSIEM | RCKVDGNHVP |
| 730 | 740 | 750 | 760 | 770 | 780 |
| DISWYKDEKL | VEEVSGIDLA | DFNQRLSIQR | VREEDAGLYL | CSVCNAKGCV | NSSASVSVEG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SDDKTNVEIV | ILIGTGVIAV | FFWILLIIIF | CNIKRPAHAD | IKTGYLSIIM | DPGEVPLEEQ |
| 850 | 860 | 870 | 880 | 890 | 900 |
| CAYLPYDSSK | WEFPRDRLRL | GKVLGHGAFG | KVVEASAFGI | NKSNSCETVA | AKMLKEGATA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| SEQKALMSEL | KILIHIGNHL | NVVNLLGACT | KPNGPLMVIV | EFCKYGNLSN | YLRTKREGFS |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| PYREKSPRLR | IQVQSIVEAV | RADRRSRSGT | SDSAIFNRFL | MHKSQTVQPI | QEVDDLWQSP |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| LTMEDLICYS | FQVARGMEFL | ASRKCIHRDL | AARNILLSEN | NVVKICDFGL | ARDIYKDPDY |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| VRKGSARLPL | KWMAPESIFD | KVYTTQSDVW | SFGVLLWEIF | SLGASPYPGV | QINEEFCQRF |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| KDGTRMRAPE | YTTAEIYRIM | LSCWHGDPKE | RPTFSDLVEI | LGNLLQENVQ | QEGKDYIPLN |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| DSHSSEDDGF | SQVPSSAQQN | SDEEDFDMRI | RCHSLAARYY | NCVSFPGCLT | GGNQIRCSSR |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| IKTFEEFPMT | HTMYKAHPDN | QTDSGMVLAS | EEFERIENRH | RKEGGFSSKG | PNRTAELSAE |
| 1330 | 1340 | 1350 | 1360 | 1370 | |
| QSDLRGRCRP | SYGSQVGGQT | FYNSEYGELS | EHSEDRSCTP | PAEGASPPAL | HASFFSEQY |