P79260

PR
Gene name
SAG
Protein name
S-arrestin
Names
48 kDa protein, Retinal S-antigen, S-AG, Rod photoreceptor arrestin
Species
Sus scrofa (Pig)
KEGG Pathway
ssc:397151
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

62-222 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P79260

Entry ID Method Resolution Chain Position Source
AF-P79260-F1 Predicted AlphaFoldDB

No variants for P79260

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P79260

No associated diseases with P79260

3 regional properties for P79260

Type Name Position InterPro Accession
domain Arrestin-like, N-terminal 26 - 182 IPR011021
domain Arrestin C-terminal-like domain 202 - 362 IPR011022
conserved_site Arrestin, conserved site 69 - 87 IPR017864

Functions

Description
EC Number
Subcellular Localization
  • Cell projection, cilium, photoreceptor outer segment
  • Membrane ; Peripheral membrane protein
  • Highly expressed in photoreceptor outer segments in light-exposed retina
  • Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity)
  • Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
photoreceptor inner segment The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.
photoreceptor outer segment The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.

1 GO annotations of molecular function

Name Definition
G protein-coupled receptor binding Binding to a G protein-coupled receptor.

2 GO annotations of biological process

Name Definition
G protein-coupled receptor internalization The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAANVQASKS TPNHVIFKKT SRDKSVTIYL GKRDYIDHVD QVEPVDGVVL VDPELVKGKR
70 80 90 100 110 120
VYVSLTCAFR YGQEDIDVIG LSFRRDLYFS QVQVFPPVGA ASQTKLQESL IKKLGGHTYP
130 140 150 160 170 180
FLLTFPDYLP CSVMLQPAPQ DVGKCCGVDF EVKAFATDSA DTGEDKIPKK SSVRLLIRKV
190 200 210 220 230 240
QHAPLEMGPQ PHAEAAWQFF MSDKPLHLTV SLSKELYYHG EPIPVTVTVT NNTEKTVKKI
250 260 270 280 290 300
KALVEQVANV VLYSSDYYIK PVATEETQQK VPPNSTLTTT LTLVPLLANN RERRGIADGK
310 320 330 340 350 360
IKHEDTNLAS STIIKEGMDK TIMGILVSYQ IKVQLTVSGL LGELTSSEVA TEVPFRLMHP
370 380 390 400
QPEDPEAMDS FQDENFVFEE FARQNLKDAG ELKEEKTDQE AAAHE