P79227

PR
Gene name
MMP12
Protein name
Macrophage metalloelastase
Names
MME, Matrix metalloproteinase-12, MMP-12
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100009559
EC number
3.4.24.65: Metalloendopeptidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

13-93 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P79227

Entry ID Method Resolution Chain Position Source
AF-P79227-F1 Predicted AlphaFoldDB

No variants for P79227

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P79227

No associated diseases with P79227

11 regional properties for P79227

Type Name Position InterPro Accession
domain Hemopexin-like domain 274 - 464 IPR000585
domain Peptidase M10, metallopeptidase 104 - 258 IPR001818
domain Peptidoglycan binding-like 22 - 82 IPR002477
domain Peptidase, metallopeptidase 100 - 259 IPR006026
conserved_site Hemopexin, conserved site 316 - 331 IPR018486
repeat Hemopexin-like repeats 274 - 325 IPR018487-1
repeat Hemopexin-like repeats 324 - 370 IPR018487-2
repeat Hemopexin-like repeats 372 - 422 IPR018487-3
repeat Hemopexin-like repeats 421 - 464 IPR018487-4
binding_site Peptidase M10A, cysteine switch, zinc binding site 85 - 92 IPR021158
domain Peptidase M10A, catalytic domain 104 - 258 IPR033739

Functions

Description
EC Number 3.4.24.65 Metalloendopeptidases
Subcellular Localization
  • Secreted, extracellular space, extracellular matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
extracellular matrix A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

2 GO annotations of molecular function

Name Definition
metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKFLLLILTL WVTSSGADPL KENDMLFAEN YLENFYGLKV ERIPMTKMKT NRNFIEEKVQ
70 80 90 100 110 120
EMQQFLGLNV TGQLDTSTLE MMHKPRCGVP DVYHFKTMPG RPVWRKHYIT YRIKNYTPDM
130 140 150 160 170 180
KREDVEYAIQ KAFQVWSDVT PLKFRKITTG KADIMILFAS GAHGDYGAFD GRGGVIAHAF
190 200 210 220 230 240
GPGPGIGGDT HFDEDEIWSK SYKGTNLFLV AVHELGHALG LDHSNDPKAI MFPTYGYIDL
250 260 270 280 290 300
NTFHLSADDI RGIQSLYGGP EQHQPMPKPD NPEPTACDHN LKFDAVTTVG NKIFFFKDSF
310 320 330 340 350 360
FWWKIPKSST TSVRLISSLW PTLPSGIEAA YEIGDRHQVF LFKGDKFWLI SHLRLQPNYP
370 380 390 400 410 420
KSIHSLGFPD FVKKIDAAVF NPSLRKTYFF VDNLYWRYDE RREVMDAGYP KLITKHFPGI
430 440 450 460
GPKIDAVFYF QRYYYFFQGP NQLEYDTFSS RVTKKLKSNS WFDC