P78972
PR
Gene name |
slp1 (SPAC821.08c) |
Protein name |
WD repeat-containing protein slp1 |
Names |
|
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC821.08c |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
2 structures for P78972
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4AEZ | X-ray | 230 A | A/D/G | 88-488 | PDB |
| AF-P78972-F1 | Predicted | AlphaFoldDB |
7 variants for P78972
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_996719_C_G | 75 | G>A | No | Jeffares_SNPs | |
| I_996498_G_A | 149 | H>Y | No | Jeffares_SNPs | |
| I_996471_T_C | 158 | T>A | No | Jeffares_SNPs | |
| I_996321_C_T | 208 | D>N | No | Jeffares_SNPs | |
| I_996134_G_A | 270 | S>F | No | Jeffares_SNPs | |
| I_996048_T_C | 299 | T>A | No | Jeffares_SNPs | |
| I_995969_T_C | 325 | D>G | No | Jeffares_SNPs |
No associated diseases with P78972
8 regional properties for P78972
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| repeat | WD40 repeat | 208 - 249 | IPR001680-1 |
| repeat | WD40 repeat | 252 - 289 | IPR001680-2 |
| repeat | WD40 repeat | 293 - 335 | IPR001680-3 |
| repeat | WD40 repeat | 335 - 377 | IPR001680-4 |
| repeat | WD40 repeat | 380 - 420 | IPR001680-5 |
| repeat | WD40 repeat | 425 - 473 | IPR001680-6 |
| conserved_site | WD40 repeat, conserved site | 319 - 333 | IPR019775 |
| domain | Anaphase-promoting complex subunit 4-like, WD40 domain | 201 - 273 | IPR024977 |
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| anaphase-promoting complex | A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B. |
| cell division site | The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. |
| kinetochore | A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. |
| mitotic checkpoint complex | A multiprotein complex that functions as a mitotic checkpoint inhibitor of the anaphase-promoting complex/cyclosome (APC/C). In budding yeast this complex consists of Mad2p, Mad3p, Bub3p and Cdc20p, and in mammalian cells it consists of MAD2, BUBR1, BUB3, and CDC20. |
| mitotic spindle | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. |
| mitotic spindle pole body | The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| anaphase-promoting complex binding | Binding to an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. |
| ubiquitin ligase activator activity | Binds to and increases the activity of a ubiquitin ligase. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| anaphase-promoting complex-dependent catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome. |
| cell division | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. |
| mitotic spindle assembly checkpoint signaling | A signal transduction process that contributes to a mitotic cell cycle spindle assembly checkpoint, that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle. |
| negative regulation of ubiquitin-protein transferase activity | Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity. |
| positive regulation of anaphase-promoting complex-dependent catabolic process | Any process that activates or increases the frequency, rate or extent of anaphase-promoting complex-dependent catabolic process. |
| positive regulation of metaphase/anaphase transition of meiosis I | Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis I. |
| positive regulation of metaphase/anaphase transition of meiosis II | Any process that activates or increases the frequency, rate or extent of metaphase/anaphase transition of meiosis II. |
| positive regulation of mitotic metaphase/anaphase transition | Any process that activates or increases the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MEIAGNSSTI | SPTFSTPTKK | RNLVFPNSPI | TPLHQQALLG | RNGRSSKRCS | PKSSFIRNSP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KIDVVNTDWS | IPLCGSPRNK | SRPASRSDRF | IPSRPNTANA | FVNSISSDVP | FDYSESVAEA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CGFDLNTRVL | AFKLDAPEAK | KPVDLRTQHN | RPQRPVVTPA | KRRFNTTPER | VLDAPGIIDD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| YYLNLLDWSN | LNVVAVALER | NVYVWNADSG | SVSALAETDE | STYVASVKWS | HDGSFLSVGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GNGLVDIYDV | ESQTKLRTMA | GHQARVGCLS | WNRHVLSSGS | RSGAIHHHDV | RIANHQIGTL |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QGHSSEVCGL | AWRSDGLQLA | SGGNDNVVQI | WDARSSIPKF | TKTNHNAAVK | AVAWCPWQSN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLATGGGTMD | KQIHFWNAAT | GARVNTVDAG | SQVTSLIWSP | HSKEIMSTHG | FPDNNLSIWS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YSSSGLTKQV | DIPAHDTRVL | YSALSPDGRI | LSTAASDENL | KFWRVYDGDH | VKRPIPITKT |
| PSSSITIR |