P78810

PR
Gene name
vtc4 (SPCC1322.14c)
Protein name
Vacuolar transporter chaperone 4
Names
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPCC1322.14c
EC number
2.7.4.1: Phosphotransferases with a phosphate group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

53-123 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P78810

Entry ID Method Resolution Chain Position Source
AF-P78810-F1 Predicted AlphaFoldDB

No variants for P78810

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P78810

No associated diseases with P78810

1 regional properties for P78810

Type Name Position InterPro Accession
conserved_site Short-chain dehydrogenase/reductase, conserved site 181 - 209 IPR020904

Functions

Description
EC Number 2.7.4.1 Phosphotransferases with a phosphate group as acceptor
Subcellular Localization
  • Vacuole membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
fungal-type vacuole membrane The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
vacuolar transporter chaperone complex A protein complex that contains four related proteins that have been implicated in several membrane-related processes, such as sorting of H+-translocating ATPases, endocytosis, ER-Golgi trafficking, vacuole fusion, vacuolar polyphosphate homeostasis and the microautophagic scission of vesicles into the vacuolar lumen. The complex is enriched at the vacuolar membrane, but also found in other cellular compartments, including the ER and the cell periphery. In Saccharomyces, the subunits are Vtc1p, Vtc2p, Vtc3p and Vtc4p.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

6 GO annotations of biological process

Name Definition
energy reserve metabolic process The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen.
lysosomal microautophagy The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment.
polyphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid.
polyphosphate metabolic process The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid.
vacuolar transport The directed movement of substances into, out of or within a vacuole.
vacuole fusion, non-autophagic The fusion of two vacuole membranes to form a single vacuole.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKFGQLLKET LMYEYKYSYV NYDKLKKEIK RRNDQGGWSE EDESDFVELL EKELDKVYSF
70 80 90 100 110 120
QKNKSAEVME RIRFCEEQTD EVVRRLDSDN PPNENDFAIL ETELTDIMAT VHDLAKFSEL
130 140 150 160 170 180
NYTAFYKIIK KHDKHTGWIL KPVFAARLNA KPFFKEQYDL LVVKLSKLYD FVRTRGSPIK
190 200 210 220 230 240
GDSAAGGTQQ NFVRQTTKYW VHPNNVTELK IYILKHLPVL VFNPNKEFAR EDAAITSIYY
250 260 270 280 290 300
DNDDLDFYLG RLEKREGAEA IRLRWYGNMD NNNIFVERKT HREDWTGEKS VKARFPLKEK
310 320 330 340 350 360
YVNAFLRGDY TVEEAFAKMR KDGKKSLKEI ESLERLAKEV QYTVLSRGMK PYVRSFYERT
370 380 390 400 410 420
AFQLPGDARV RISLDTNLSL IREDGPSRAG NNWRRMDIGI DYPFDQLPDE DIVRFPYAIL
430 440 450 460 470 480
EVKLQTQFGQ DPPEWVNNLV NSHLVEAVPK FSKFIHGVST LFYDRVTLLP YWFPQMDIDI
490 500 510 520 530 540
RKPATHTFIQ GRSQSGTHSS SVSANVLTDS ENTPIHADGD NYVDEESRIG SSSTRNDNST
550 560 570 580 590 600
FQTSDSFQEL DERTNLLDIS KRKGRDSFVA ALNSRLKDIK DSFFLETVPK FEEPTEPTVI
610 620 630 640 650 660
YEQKYVSPPG KRIYVPVRVE PKTYFALERT YLDYLRYSIL MGSIGITLFS FAKTRSGILG
670 680 690 700 710 720
AASFTLVALF AIFYSTFLYL WRAVNIAKHN AVRYDDRFGP TAICVITFAA ISANVILNFN
A