P78759
Gene name |
par2 (pbp2, SPAC6F12.12) |
Protein name |
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta 2 isoform |
Names |
PP2A, B subunit, B' delta 2 isoform |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC6F12.12 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P78759
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P78759-F1 | Predicted | AlphaFoldDB |
5 variants for P78759
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_1335995_A_T | 23 | N>I | No | Jeffares_SNPs | |
| I_1336306_C_T | 127 | P>S | No | Jeffares_SNPs | |
| I_1337934_C_T | 588 | L>F | No | Jeffares_SNPs | |
| I_1337955_G_A | 595 | A>T | No | Jeffares_SNPs | |
| I_1337962_T_A | 597 | I>K | No | Jeffares_SNPs |
No associated diseases with P78759
1 regional properties for P78759
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Cytidyltransferase-like domain | 26 - 77 | IPR004821 |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| cell division site | The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. |
| cell tip | The region at the end of the longest axis of a cylindrical or elongated cell. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| protein phosphatase type 2A complex | A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| protein phosphatase regulator activity | Binds to and modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| negative regulation of septation initiation signaling | Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling. |
| signal transduction | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKGLRSKFVK | ALSLKDEQGS | HKNGHSKSHY | ISKNGSYVET | DDVKHTDTHH | SSKHELKKLK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| SHFLKDTLKH | KRNHHANSNN | EKHENSDKKI | HTTVLASGHE | DSDYSTFLPV | IETSKVKDAN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HFPPNYPEPK | NDSVSSNIDE | FPNDSISSAS | FLSVPQSTPP | YLVSQPTPLN | KFLAGAENVD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IPHSLRPVPR | REHSSQFQVS | EKRTLVRLPS | FDDVHTSERE | ELFIKKLEQC | NIIFDFNDPS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SDLASKEIKR | EALLQMIDYV | SENRGISSAS | LFPYVVNTFS | LNVFRPISPA | LNDYSSDMFA |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LDDEPFLEPA | WPHLEEVYLL | FIKFLESPDF | RASKAKSLVD | RRFFNRLLAL | FDTEDPRERE |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LLKTTLHRIY | GKFLNLRSYI | RKSMNNVFLQ | FIYEREKFHG | IAELLEILGS | IINGFAVPLK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EEHKIFLSKV | LIPLHQTKSV | FLYHPQLTYC | IVQFIDKDPS | LTKAVLTGIL | KYWPRINSFK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ELLFLNEIED | IFEVLEPSEF | VNIMSPLFQQ | LARSISSMHF | QVAERALCLW | SNEYFTSLVS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| QNVVTLLPII | YPSLYKTANE | HWNSTIQAIA | CNVLQIFVDM | DADFFNGLVE | DYKQAIIKQE |
| 610 | 620 | ||||
| EVMIIRKQQW | CQIEALAAEN | KPTDYLR |