P78697

PR
Gene name
DIM1 (KLLA0D00594g)
Protein name
Dimethyladenosine transferase
Names
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase, 18S rRNA dimethylase, S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Species
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
KEGG Pathway
kla:KLLA0_D00594g
EC number
2.1.1.183: Methyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P78697

Entry ID Method Resolution Chain Position Source
AF-P78697-F1 Predicted AlphaFoldDB

No variants for P78697

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P78697

No associated diseases with P78697

2 regional properties for P78697

Type Name Position InterPro Accession
conserved_site Ribosomal RNA adenine methylase transferase, conserved site 61 - 88 IPR020596
domain Ribosomal RNA adenine methylase transferase, N-terminal 45 - 214 IPR020598

Functions

Description
EC Number 2.1.1.183 Methyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.

2 GO annotations of molecular function

Name Definition
18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity Catalysis of the reaction: 4 S-adenosyl-L-methionine + adenine(1779)/adenine(1780) in 18S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1779)/N(6)-dimethyladenine(1780) in 18S rRNA.
RNA binding Binding to an RNA molecule or a portion thereof.

1 GO annotations of biological process

Name Definition
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGKAVKKKYS GASSGGKEVD AEKHLTTVFK FNTDLGQHIL KNPLVAQGIV DKAQIKPSDI
70 80 90 100 110 120
VLEIGPGTGN LTVRILEQAR KVVAVEFDPR MAAELTKRVH GTPVEKKLEI LLGDFMKTEL
130 140 150 160 170 180
PYFDVCISNT PYQISSPLVF KLINQPKPPR VSILMFQREF AMRLLARPGD SLYCRLSANV
190 200 210 220 230 240
QMWANVTHIM KVGKNNFRPP PKVESSVVRI EIKNPRPQVD FNEWDGLLRI VFVRKNRTIA
250 260 270 280 290 300
AGFKSTTVLE ILEKNYKAFL ATQSAVPTTS SGDSLINEVK EKIEQVLSET GLAEKRAGKC
310
DQTDFLKLLY GFHQVGIHFA