AiPD: Autoinhibited Protein Database

P78380

Gene name	OLR1 (CLEC8A, LOX1)
Protein name	Oxidized low-density lipoprotein receptor 1
Names	Ox-LDL receptor 1, C-type lectin domain family 8 member A, Lectin-like oxidized LDL receptor 1, LOX-1, Lectin-like oxLDL receptor 1, hLOX-1, Lectin-type oxidized LDL receptor 1
Species	Homo sapiens (Human)
KEGG Pathway	hsa:4973
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-165 (Predicted disordered autoinhibitory region) PR

Target domain
Relief mechanism
Assay	cis-regPred

AID

1-165 (Predicted disordered autoinhibitory region)

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Yeon JH et al. (2016) "Systems-wide Identification of cis-Regulatory Elements in Proteins", Cell Systems, 2, 89-100

Autoinhibited structure

Activated structure

13 structures for P78380

Entry ID	Method	Resolution	Chain	Position	Source
1YPO	X-ray	300 A	A/B/C/D/E/F/G/H	142-272	PDB
1YPQ	X-ray	140 A	A/B	136-270	PDB
1YPU	X-ray	205 A	A/B	136-270	PDB
1YXJ	X-ray	178 A	A/B	143-271	PDB
1YXK	X-ray	240 A	A/B	136-270	PDB
3VLG	X-ray	230 A	A	133-273	PDB
6TL7	X-ray	111 A	A/B	143-273	PDB
6TL9	X-ray	273 A	A/B/C/D/E/F/G/H	143-273	PDB
6TLA	X-ray	216 A	A/B/C	129-273	PDB
7R8U	X-ray	190 A	AAA/BBB	140-271	PDB
7W5D	X-ray	114 A	A/B	136-273	PDB
7XMP	X-ray	127 A	A	136-273	PDB
AF-P78380-F1	Predicted				AlphaFoldDB

207 variants for P78380

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
rs11053646 VAR_023200 RCV001799590 CA118582	167	K>N	Myocardial infarction, susceptibility to myocardial infarction susceptibility [ClinVar, UniProt]	Yes	ClinGen ClinVar UniProt 1000Genomes ESP ExAC TOPMed dbSNP gnomAD
rs1267818705 CA383881300	5	D>Y		No	ClinGen TOPMed
CA383881279 rs1193435510	8	I>F		No	ClinGen TOPMed gnomAD
rs1193435510 CA383881280	8	I>V		No	ClinGen TOPMed gnomAD
rs952517105 CA232811163	9	Q>H		No	ClinGen Ensembl
CA383881263 rs1565423521	10	T>S		No	ClinGen Ensembl
CA6444441 rs779706155	11	V>A		No	ClinGen ExAC gnomAD
CA6444440 rs779706155	11	V>E		No	ClinGen ExAC gnomAD
CA383881253 rs1209545375	12	K>R		No	ClinGen gnomAD
rs1157378441 CA383881248	13	D>H		No	ClinGen TOPMed
CA6444438 rs751951658	15	P>L		No	ClinGen ExAC TOPMed gnomAD
rs757897159 CA6444439	15	P>T		No	ClinGen ExAC TOPMed gnomAD
rs764522550 CA6444437	17	E>K		No	ClinGen ExAC gnomAD
rs1363964661 CA383881214	18	K>Q		No	ClinGen TOPMed
CA232811148 rs141892646	20	N>S		No	ClinGen ESP TOPMed
rs994354306 CA232811145 COSM257601	22	K>*	large_intestine Variant assessed as Somatic; impact. [Cosmic, NCI-TCGA]	No	ClinGen cosmic curated Ensembl NCI-TCGA
rs1312687978 CA383881174	23	K>N		No	ClinGen gnomAD
CA232811138 rs895561791	24	A>G		No	ClinGen Ensembl
rs747703868	24	A>L	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	24	A>S	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs758642110 CA6444435	25	K>E		No	ClinGen ExAC gnomAD
rs1364146823 CA383881158	26	G>C		No	ClinGen gnomAD
rs1175621412 CA383881133	28	Q>R	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA gnomAD
rs778195143 CA6444417	30	L>P		No	ClinGen ExAC TOPMed gnomAD
CA6444416 rs148551872 COSM1579781	32	S>C	central_nervous_system [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
CA6444415 rs753070166	33	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
CA383881091 rs1341938679	34	W>*		No	ClinGen gnomAD
rs755209727 CA6444413	34	W>R		No	ClinGen ExAC gnomAD
CA383881087 rs1408756043	35	W>*		No	ClinGen gnomAD
CA6444411 rs199668224	35	W>C		No	ClinGen ExAC gnomAD
rs753995695 CA6444412	35	W>R		No	ClinGen ExAC gnomAD
rs760694441 CA6444410	37	L>M		No	ClinGen ExAC gnomAD
rs750491095 CA6444409	40	A>V		No	ClinGen ExAC TOPMed gnomAD
CA383881044 rs1163080524	42	L>P		No	ClinGen gnomAD
rs1458600048 CA383881041	43	G>R		No	ClinGen gnomAD
rs761802764 CA383881034	44	V>F		No	ClinGen ExAC TOPMed gnomAD
rs761802764 CA6444407	44	V>I		No	ClinGen ExAC TOPMed gnomAD
rs768512963 CA6444405	45	L>F		No	ClinGen ExAC TOPMed gnomAD
CA383881030 rs768512963	45	L>I		No	ClinGen ExAC TOPMed gnomAD
rs1252664148 CA383881024	46	C>R		No	ClinGen gnomAD
rs769549605 CA6444402	49	L>S		No	ClinGen ExAC TOPMed gnomAD
CA6444400 rs780750116	50	V>A		No	ClinGen ExAC gnomAD
rs201528781 COSM328309 CA6444401	50	V>I	pancreas [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs1342432898 CA383880991	51	V>E		No	ClinGen gnomAD
rs1258526911 CA383880996	51	V>M		No	ClinGen gnomAD
TCGA novel	53	I>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1329192290 CA383880983	53	I>V		No	ClinGen gnomAD
CA6444398 rs779258210	54	M>K		No	ClinGen ExAC gnomAD
rs772513636 CA6444399	54	M>L		No	ClinGen ExAC gnomAD
rs779258210 CA6444397	54	M>T		No	ClinGen ExAC gnomAD
CA383880977 rs772513636	54	M>V		No	ClinGen ExAC gnomAD
rs1287732483 CA383880960	57	G>R		No	ClinGen TOPMed
rs755299237 CA6444396	57	G>V		No	ClinGen ExAC gnomAD
CA6444395 rs754085626	58	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA
rs780301046 CA6444394	59	Q>P		No	ClinGen ExAC gnomAD
rs1401595592 CA383880913	62	Q>*		No	ClinGen gnomAD
rs1049843352 CA232809264	67	L>P		No	ClinGen TOPMed
rs781134192 CA6444373	68	T>A		No	ClinGen ExAC gnomAD
rs1266244478 CA383880873	68	T>I		No	ClinGen TOPMed
rs1188586191 CA383880871	69	Q>E		No	ClinGen Ensembl
CA6444372 rs757319493	70	E>Q		No	ClinGen ExAC gnomAD
rs984973463 CA232809249	72	A>G		No	ClinGen TOPMed gnomAD
CA383880845 rs984973463	72	A>V		No	ClinGen TOPMed gnomAD
CA383880840 rs1437261724	73	N>S		No	ClinGen gnomAD
TCGA novel	73	N>T	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs751563256 CA6444371	74	L>P		No	ClinGen ExAC TOPMed gnomAD
CA383880824 rs1249438944	76	H>Y		No	ClinGen gnomAD
CA6444370 rs764168288	78	K>R		No	ClinGen ExAC gnomAD
CA6444367 TCGA novel rs765026246	79	K>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen ExAC TOPMed gnomAD NCI-TCGA
rs758406657 CA6444369	79	K>T		No	ClinGen ExAC gnomAD
CA383880778 rs1450128955	82	E>D		No	ClinGen TOPMed
rs1196455656 CA383880776	83	G>R	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs149425676 CA6444366	84	Q>E		No	ClinGen ESP ExAC TOPMed gnomAD
rs776310061 CA6444365	84	Q>P		No	ClinGen ExAC TOPMed gnomAD
CA232809223 rs374536619	86	S>L		No	ClinGen ESP TOPMed gnomAD
CA383880752 rs1272965420	87	A>T		No	ClinGen gnomAD
CA6444364 rs765832794	87	A>V		No	ClinGen ExAC TOPMed gnomAD
rs760230693 CA383880746	88	R>G		No	ClinGen ExAC TOPMed gnomAD
CA383880744 rs371146790	88	R>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs371146790 CA6444362 COSM3772229	88	R>Q	pancreas [Cosmic]	No	ClinGen cosmic curated ESP ExAC TOPMed gnomAD
rs760230693 CA6444363	88	R>W		No	ClinGen ExAC TOPMed gnomAD
rs749779571 CA6444360	92	E>G		No	ClinGen ExAC TOPMed gnomAD
CA6444361 rs769214390	92	E>K		No	ClinGen ExAC gnomAD
CA6444359 rs139401310	93	E>A		No	ClinGen ESP ExAC TOPMed gnomAD
rs770127699 CA6444358	94	A>T		No	ClinGen ExAC TOPMed gnomAD
TCGA novel	96	Q>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6444355 rs781426287	96	Q>P		No	ClinGen ExAC gnomAD
rs1357403753 CA383880677	98	S>L		No	ClinGen TOPMed
TCGA novel	99	E>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1189099806 CA383880660	101	E>*		No	ClinGen TOPMed gnomAD
CA383880659 rs1189099806	101	E>K		No	ClinGen TOPMed gnomAD
CA232809186 rs1009368070	101	E>V		No	ClinGen TOPMed gnomAD
CA383880651 rs1273038922	102	L>F		No	ClinGen gnomAD
rs142675845 CA6444351	104	E>K		No	ClinGen ESP ExAC TOPMed gnomAD
TCGA novel	105	M>I	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1274777992 CA383880617	106	I>M		No	ClinGen TOPMed
CA383880618 rs1403128339	106	I>R		No	ClinGen Ensembl
rs758425239 CA6444350	111	R>Q		No	ClinGen ExAC TOPMed gnomAD
rs892229108 CA232809175	111	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA6444347 rs368435897	114	N>S		No	ClinGen ExAC gnomAD
CA6444346 rs753556915	116	K>I		No	ClinGen ExAC TOPMed gnomAD
CA383880525 rs1410377479	120	Q>L		No	ClinGen gnomAD
CA383880514 rs1162478959	121	M>I		No	ClinGen gnomAD
CA383880521 rs1372153845	121	M>V		No	ClinGen TOPMed gnomAD
CA383880497 rs1404388626	124	H>Y		No	ClinGen TOPMed gnomAD
CA383880467 rs1169295891	127	N>I		No	ClinGen TOPMed
CA383880416 rs1471286934	132	E>G		No	ClinGen TOPMed gnomAD
rs766092711 CA6444345	132	E>K		No	ClinGen ExAC gnomAD
rs555545113 CA6444344	135	K>E		No	ClinGen ExAC TOPMed gnomAD
rs749991493 CA383880378	136	R>K		No	ClinGen ExAC TOPMed gnomAD
CA6444343 rs749991493	136	R>T		No	ClinGen ExAC TOPMed gnomAD
CA232809156 rs1019193521	137	V>A		No	ClinGen TOPMed
CA383880373 rs1425785894	137	V>I		No	ClinGen TOPMed
rs1425785894 CA383880371	137	V>L		No	ClinGen TOPMed
rs1219917086 CA383880358	138	A>E		No	ClinGen gnomAD
CA6444342 rs766952879	138	A>T		No	ClinGen ExAC gnomAD
rs765840296 CA6444322	142	A>D		No	ClinGen ExAC gnomAD
CA383879339 rs1299024640	143	P>H		No	ClinGen TOPMed gnomAD
CA383879340 rs1299024640	143	P>L		No	ClinGen TOPMed gnomAD
rs759947861 CA6444321	145	P>L		No	ClinGen ExAC TOPMed gnomAD
CA6444319 rs761012790	149	I>M		No	ClinGen ExAC TOPMed gnomAD
CA383879285 rs1432409231	151	H>N		No	ClinGen gnomAD
rs1049112315 CA232806782	151	H>R		No	ClinGen TOPMed
rs1351722170 CA383879278	152	G>R		No	ClinGen TOPMed gnomAD
rs773520812 CA6444317	155	C>S		No	ClinGen ExAC gnomAD
CA6444315 rs372771543	158	F>L		No	ClinGen ESP ExAC TOPMed gnomAD
rs778851250 CA6444314	159	S>P		No	ClinGen ExAC gnomAD
rs768691963 CA6444313	160	S>L		No	ClinGen ExAC TOPMed gnomAD
CA383879210 rs1345856213	162	S>L		No	ClinGen TOPMed
rs1347145798 CA383879198	164	N>D		No	ClinGen TOPMed gnomAD
CA383879199 rs1347145798	164	N>H		No	ClinGen TOPMed gnomAD
rs201129982 CA6444311	166	E>G		No	ClinGen ExAC TOPMed gnomAD
CA6444308 rs756870922	171	K>E		No	ClinGen ExAC gnomAD
CA232806724 rs1050444516	173	L>F		No	ClinGen TOPMed gnomAD
CA6444304 rs754260673 CA6444305	176	D>E		No	ClinGen ExAC TOPMed gnomAD
rs1282198225 CA383879085	179	L>F		No	ClinGen gnomAD
CA383879086 rs1591979216	179	L>W		No	ClinGen Ensembl
CA383879078 rs766875651	181	K>E		No	ClinGen ExAC TOPMed gnomAD
rs766875651 CA6444303	181	K>Q		No	ClinGen ExAC TOPMed gnomAD
CA383879063 rs1432356994	183	N>D		No	ClinGen TOPMed
rs761172569 CA6444302	184	S>I		No	ClinGen ExAC gnomAD
CA6444301 rs773684434	186	A>D		No	ClinGen ExAC gnomAD
rs1297819608 CA383879042	186	A>P		No	ClinGen gnomAD
CA383879030 rs1385229188	188	L>M		No	ClinGen TOPMed
CA383879000 rs1408563065	190	F>S		No	ClinGen gnomAD
rs140784946 CA6444284	191	I>V		No	ClinGen ESP ExAC TOPMed
rs1433551142 CA383878985	192	Q>*		No	ClinGen TOPMed gnomAD
rs1433551142 CA383878987	192	Q>K		No	ClinGen TOPMed gnomAD
CA383878964 rs1383711004	194	A>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed
rs267603272 CA232806412	196	S>F		No	ClinGen Ensembl
rs762096669 CA6444281	197	Y>F		No	ClinGen ExAC gnomAD
rs1463721021 CA383878945	197	Y>H		No	ClinGen gnomAD
TCGA novel	199	S>N	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
TCGA novel	202	F>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA6444279 rs764254752	204	M>I		No	ClinGen ExAC gnomAD
rs371858766 CA6444280	204	M>T		No	ClinGen ESP ExAC TOPMed gnomAD
CA232806386 rs775516504	208	R>G		No	ClinGen ExAC TOPMed gnomAD
COSM180533 rs769789426 CA6444276	208	R>Q	Variant assessed as Somatic; 0.0 impact. large_intestine [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ExAC NCI-TCGA TOPMed gnomAD
CA6444277 rs775516504	208	R>W	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
rs373022812 CA6444275	209	R>K		No	ClinGen 1000Genomes ESP ExAC TOPMed gnomAD
rs1253898313 CA383878837	210	N>D		No	ClinGen TOPMed
TCGA novel	210	N>K	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs186250314 CA6444274	212	S>N		No	ClinGen 1000Genomes ExAC gnomAD
CA383878814 rs1378598511	212	S>R		No	ClinGen gnomAD
CA6444273 rs770593146	214	P>L		No	ClinGen ExAC gnomAD
rs1264426225 CA383878803	214	P>T		No	ClinGen TOPMed gnomAD
rs1261624919 CA383878795	215	W>R		No	ClinGen TOPMed
CA383878776 rs1448256575	217	W>*		No	ClinGen TOPMed
rs747731348 CA6444270	220	G>C		No	ClinGen ExAC gnomAD
CA6444269 rs747731348	220	G>S		No	ClinGen ExAC gnomAD
rs1393446830 CA383878397	221	S>F		No	ClinGen gnomAD
rs1389033534 CA383878341	225	P>S	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
CA383878323 rs1462206660	226	H>Q		No	ClinGen gnomAD
rs1395727020 CA383878326	226	H>R		No	ClinGen TOPMed
rs1434195682 CA383878320	227	L>V		No	ClinGen TOPMed
rs1056125322 CA232806156	230	V>I		No	ClinGen TOPMed
rs199989233 CA6444244	231	R>*		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs199989233 CA383878280	231	R>G		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA232806155 rs986422401	231	R>Q	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen NCI-TCGA TOPMed gnomAD
rs535180296 CA6444242	233	A>T	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA gnomAD
rs778185706 CA6444241	234	V>F		No	ClinGen ExAC
rs763828543 CA6444240	235	S>A		No	ClinGen ExAC gnomAD
CA383878257 rs1434673386	235	S>F		No	ClinGen gnomAD
rs1591978712 CA383878232	239	P>S		No	ClinGen Ensembl
TCGA novel	241	G>V	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
rs1401481108 CA383878202	244	A>T		No	ClinGen gnomAD
CA232806125 rs1045169061	245	Y>C		No	ClinGen TOPMed
rs374394285 CA6444237 COSM3383975	248	R>*	Variant assessed as Somatic; 0.0 impact. pancreas [NCI-TCGA, Cosmic]	No	ClinGen cosmic curated ESP ExAC NCI-TCGA gnomAD
rs897928133 CA232806120	251	V>L		No	ClinGen Ensembl
CA6444235 rs374494106	253	A>G		No	ClinGen ExAC TOPMed gnomAD
rs374494106 CA6444234	253	A>V	Variant assessed as Somatic; 0.0 impact. [NCI-TCGA]	No	ClinGen ExAC NCI-TCGA TOPMed gnomAD
CA383878123 rs1184848638	255	N>K		No	ClinGen gnomAD
CA383878128 rs1189764015	255	N>Y		No	ClinGen TOPMed
CA383878119 rs1441345415	256	C>Y		No	ClinGen gnomAD
CA6444232 rs771828476	260	A>V		No	ClinGen ExAC TOPMed gnomAD
rs577739742 CA6444230	262	S>I		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs577739742 CA6444231	262	S>N		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
CA383878074 rs1477039270	263	I>V		No	ClinGen TOPMed gnomAD
CA383878045 rs1410024324	266	K>N		No	ClinGen TOPMed
CA6444229 rs143492178	267	K>E		No	ClinGen ESP ExAC TOPMed
rs368924076 CA232806083	269	N>I		No	ClinGen ESP
CA6444228 rs557756840	271	R>T		No	ClinGen 1000Genomes ExAC TOPMed gnomAD
rs1436152952 CA383878008	272	A>V		No	ClinGen TOPMed
rs1313134582 CA383878007	273	Q>K		No	ClinGen TOPMed
CA383878003 rs1313373404	273	Q>R		No	ClinGen gnomAD
TCGA novel	274	Q>L	Variant assessed as Somatic; impact. [NCI-TCGA]	No	NCI-TCGA
CA383877994 rs1340184018	274	Q>W		No	ClinGen TOPMed

No associated diseases with P78380

2 regional properties for P78380

Type	Name	Position	InterPro Accession
domain	Integrase, catalytic domain	326 - 513	IPR002104
domain	Core-binding (CB) domain	216 - 302	IPR044068

Functions

		Description
EC Number
Subcellular Localization	Cell membrane; Lipid-anchor Cell membrane; Single-pass type II membrane protein Membrane raft Secreted	A secreted form also exists Localization to membrane rafts requires palmitoylation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

10 GO annotations of cellular component

Name	Definition
extracellular region	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
integral component of plasma membrane	The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
intracellular membrane-bounded organelle	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
membrane	A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
membrane raft	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
nucleoplasm	That part of the nuclear content other than the chromosomes or the nucleolus.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
receptor complex	Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.
specific granule membrane	The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.
tertiary granule membrane	The lipid bilayer surrounding a tertiary granule.

3 GO annotations of molecular function

Name	Definition
carbohydrate binding	Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
identical protein binding	Binding to an identical protein or proteins.
low-density lipoprotein particle receptor activity	Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.

7 GO annotations of biological process

Name	Definition
blood circulation	The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.
cell death	Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).
immune system process	Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.
inflammatory response	The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
leukocyte cell-cell adhesion	The attachment of a leukocyte to another cell via adhesion molecules.
lipoprotein metabolic process	The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.
proteolysis	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

1 homologous proteins in AiPD

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
P25031	Reg3b	Regenerating islet-derived protein 3-beta	Rattus norvegicus (Rat)	PR

10	20	30	40	50	60
MTFDDLKIQT	VKDQPDEKSN	GKKAKGLQFL	YSPWWCLAAA	TLGVLCLGLV	VTIMVLGMQL
70	80	90	100	110	120
SQVSDLLTQE	QANLTHQKKK	LEGQISARQQ	AEEASQESEN	ELKEMIETLA	RKLNEKSKEQ
130	140	150	160	170	180
MELHHQNLNL	QETLKRVANC	SAPCPQDWIW	HGENCYLFSS	GSFNWEKSQE	KCLSLDAKLL
190	200	210	220	230	240
KINSTADLDF	IQQAISYSSF	PFWMGLSRRN	PSYPWLWEDG	SPLMPHLFRV	RGAVSQTYPS
250	260	270
GTCAYIQRGA	VYAENCILAA	FSICQKKANL	RAQ