P77837
Gene name |
ureC |
Protein name |
Urease subunit alpha |
Names |
Urea amidohydrolase subunit alpha |
Species |
Bacillus subtilis (strain 168) |
KEGG Pathway |
bsu:BSU36640 |
EC number |
3.5.1.5: In linear amides |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P77837
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P77837-F1 | Predicted | AlphaFoldDB |
No variants for P77837
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P77837 | |||||
No associated diseases with P77837
5 regional properties for P77837
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Amidohydrolase-related | 128 - 455 | IPR006680 |
| domain | Urease alpha-subunit, N-terminal domain | 1 - 122 | IPR011612 |
| active_site | Urease active site | 320 - 336 | IPR017950 |
| domain | Urease alpha subunit, C-terminal | 132 - 569 | IPR017951 |
| binding_site | Urease nickel binding site | 130 - 143 | IPR029754 |
Functions
| Description | ||
|---|---|---|
| EC Number | 3.5.1.5 | In linear amides |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| nickel cation binding | Binding to a nickel (Ni) cation. |
| urease activity | Catalysis of the reaction: urea + H2O = CO2 + 2 NH3. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| urea catabolic process | The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKMSREEYAE | LFGPTTGDKI | RLGDTDLWIE | VEKDFTVYGE | EMIFGGGKTI | RDGMGQNGRI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TGKDGALDLV | ITNVVLLDYT | GIVKADVGVK | DGRIVGVGKS | GNPDIMDGVD | PHMVIGAGTE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VISGEGKILT | AGGVDTHIHF | ICPQQMEVAL | SSGVTTLLGG | GTGPATGSKA | TTCTSGAWYM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ARMLEAAEEF | PINVGFLGKG | NASDKAPLIE | QVEAGAIGLK | LHEDWGTTPS | AIKTCMEVVD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EADIQVAIHT | DTINEAGFLE | NTLDAIGDRV | IHTYHIEGAG | GGHAPDIMKL | ASYANILPSS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| TTPTIPYTVN | TMDEHLDMMM | VCHHLDAKVP | EDVAFSHSRI | RAATIAAEDI | LHDIGAISMT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SSDSQAMGRV | GEVIIRTWQV | ADKMKKQRGA | LAGENGNDNV | RAKRYIAKYT | INPAITHGLS |
| 430 | 440 | 450 | 460 | 470 | 480 |
| HEVGSVEKGK | LADLVLWDPV | FFGVKPELVL | KGGMIARAQM | GDPNASIPTP | EPVFMRQMYA |
| 490 | 500 | 510 | 520 | 530 | 540 |
| SYGKANRSTS | ITFMSQASIE | RGVAESLGLE | KRISPVKNIR | KLSKLDMKLN | SALPKIEIDP |
| 550 | 560 | ||||
| KTYQVFADGE | ELSCQPVDYV | PLGQRYFLF |