P77334

PR
Gene name
pdeR
Protein name
Cyclic di-GMP phosphodiesterase PdeR
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1285
EC number
3.1.4.52: Phosphoric diester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-139 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P77334

Entry ID Method Resolution Chain Position Source
AF-P77334-F1 Predicted AlphaFoldDB

No variants for P77334

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P77334

No associated diseases with P77334

3 regional properties for P77334

Type Name Position InterPro Accession
domain PAS domain 109 - 233 IPR000014
domain GGDEF domain 226 - 397 IPR000160
domain EAL domain 405 - 658 IPR001633

Functions

Description
EC Number 3.1.4.52 Phosphoric diester hydrolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
cyclic-guanylate-specific phosphodiesterase activity Catalysis of the reaction: cyclic di-3',5'-guanylate + H(2)O = 5'-phosphoguanylyl(3'->5')guanosine + H(+).
GTP binding Binding to GTP, guanosine triphosphate.

2 GO annotations of biological process

Name Definition
negative regulation of cyclase activity Any process that stops or reduces the activity of a cyclase.
post-transcriptional regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTVRESTTL YNFLGSHNPY WRLTESSDVL RFSTTETTEP DRTLQLSAEQ AARIREMTVI
70 80 90 100 110 120
TSSLMMSLTV DESDLSVHLV GRKINKREWA GNASAWHDTP AVARDLSHGL SFAEQVVSEA
130 140 150 160 170 180
HSAIVILDSR GNIQRFNRLC EDYTGLKEHD VIGQSVFKLF MSRREAAASR RNNRVFFRSG
190 200 210 220 230 240
NAYEVELWIP TCKGQRLFLF RNKFVHSGSG KNEIFLICSG TDITEERRAQ ERLRILANTD
250 260 270 280 290 300
SITGLPNRNA MQDLIDHAIN HADNNKVGVV YLDLDNFKKV NDAYGHLFGD QLLRDVSLAI
310 320 330 340 350 360
LSCLEHDQVL ARPGGDEFLV LASNTSQSAL EAMASRILTR LRLPFRIGLI EVYTSCSVGI
370 380 390 400 410 420
ALSPEHGSDS TAIIRHADTA MYTAKEGGRG QFCVFTPEMN QRVFEYLWLD TNLRKALEND
430 440 450 460 470 480
QLVIHYQPKI TWRGEVRSLE ALVRWQSPER GLIPPLDFIS YAEESGLIVP LGRWVILDVV
490 500 510 520 530 540
RQVAKWRDKG INLRVAVNIS ARQLADQTIF TALKQVLQEL NFEYCPIDVE LTESCLIEND
550 560 570 580 590 600
ELALSVIQQF SQLGAQVHLD DFGTGYSSLS QLARFPIDAI KLDQVFVRDI HKQPVSQSLV
610 620 630 640 650 660
RAIVAVAQAL NLQVIAEGVE SAKEDAFLTK NGINERQGFL FAKPMPAVAF ERWYKRYLKR
A