P77161

PR
Gene name
glxR (glxB1, ybbQ, b0509, JW0497)
Protein name
2-hydroxy-3-oxopropionate reductase
Names
Tartronate semialdehyde reductase, TSAR
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0509
EC number
1.1.1.60: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

78-148 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P77161

Entry ID Method Resolution Chain Position Source
AF-P77161-F1 Predicted AlphaFoldDB

No variants for P77161

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P77161

No associated diseases with P77161

3 regional properties for P77161

Type Name Position InterPro Accession
conserved_site 3-hydroxyisobutyrate dehydrogenase-related, conserved site 5 - 18 IPR002204
domain 6-phosphogluconate dehydrogenase, NADP-binding 2 - 160 IPR006115
domain 3-hydroxyisobutyrate dehydrogenase-like, NAD-binding domain 163 - 283 IPR029154

Functions

Description
EC Number 1.1.1.60 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
2-hydroxy-3-oxopropionate reductase activity Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+.
NAD binding Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH.
NADP binding Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH.
tartronate semialdehyde reductase activity Catalysis of the reaction: D-glycerate + NAD <=> H+ + 2-hydroxy-3-oxopropanoate + NADH.

4 GO annotations of biological process

Name Definition
allantoin assimilation pathway The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP.
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
glycolate catabolic process The chemical reactions and pathways resulting in the breakdown of glycolate, the anion of hydroxyethanoic acid (glycolic acid).
glyoxylate catabolic process The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKLGFIGLGI MGTPMAINLA RAGHQLHVTT IGPVADELLS LGAVSVETAR QVTEASDIIF
70 80 90 100 110 120
IMVPDTPQVE EVLFGENGCT KASLKGKTIV DMSSISPIET KRFARQVNEL GGDYLDAPVS
130 140 150 160 170 180
GGEIGAREGT LSIMVGGDEA VFERVKPLFE LLGKNITLVG GNGDGQTCKV ANQIIVALNI
190 200 210 220 230 240
EAVSEALLFA SKAGADPVRV RQALMGGFAS SRILEVHGER MIKRTFNPGF KIALHQKDLN
250 260 270 280 290
LALQSAKALA LNLPNTATCQ ELFNTCAANG GSQLDHSALV QALELMANHK LA