P76469

PR
Gene name
rhmA (yfaU, b2245, JW2239)
Protein name
2-keto-3-deoxy-L-rhamnonate aldolase
Names
KDR aldolase, 2-dehydro-3-deoxyrhamnonate aldolase, 2-keto-3-deoxy acid sugar aldolase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b2245
EC number
4.1.2.53: Aldehyde-lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

74-144 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P76469

Entry ID Method Resolution Chain Position Source
2VWS X-ray 139 A A/B/C 1-267 PDB
2VWT X-ray 193 A A/B/C 1-267 PDB
AF-P76469-F1 Predicted AlphaFoldDB

No variants for P76469

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P76469

No associated diseases with P76469

1 regional properties for P76469

Type Name Position InterPro Accession
domain HpcH/HpaI aldolase/citrate lyase domain 19 - 245 IPR005000

Functions

Description
EC Number 4.1.2.53 Aldehyde-lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

5 GO annotations of molecular function

Name Definition
2-keto-3-deoxy-L-rhamnonate aldolase activity Catalysis of the reaction 2-dehydro-3-deoxy-L-rhamnonate = pyruvate + (S)-lactaldehyde.
aldehyde-lyase activity Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone.
identical protein binding Binding to an identical protein or proteins.
magnesium ion binding Binding to a magnesium (Mg) ion.
nickel cation binding Binding to a nickel (Ni) cation.

1 GO annotations of biological process

Name Definition
protein hexamerization The formation of a protein hexamer, a macromolecular structure consisting of six noncovalently associated identical or nonidentical subunits.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNALLSNPFK ERLRKGEVQI GLWLSSTTAY MAEIAATSGY DWLLIDGEHA PNTIQDLYHQ
70 80 90 100 110 120
LQAVAPYASQ PVIRPVEGSK PLIKQVLDIG AQTLLIPMVD TAEQARQVVS ATRYPPYGER
130 140 150 160 170 180
GVGASVARAA RWGRIENYMA QVNDSLCLLV QVESKTALDN LDEILDVEGI DGVFIGPADL
190 200 210 220 230 240
SASLGYPDNA GHPEVQRIIE TSIRRIRAAG KAAGFLAVAP DMAQQCLAWG ANFVAVGVDT
250 260
MLYSDALDQR LAMFKSGKNG PRIKGSY