P76037

PR
Gene name
puuP
Protein name
Putrescine importer PuuP
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1296
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-47 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P76037

Entry ID Method Resolution Chain Position Source
AF-P76037-F1 Predicted AlphaFoldDB

No variants for P76037

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P76037

No associated diseases with P76037

1 regional properties for P76037

Type Name Position InterPro Accession
domain Amino acid permease/ SLC12A domain 27 - 408 IPR004841

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

2 GO annotations of molecular function

Name Definition
putrescine transmembrane transporter activity Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.
solute:proton symporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in).

4 GO annotations of biological process

Name Definition
amino acid transport The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
putrescine catabolic process The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine.
putrescine transport The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAINSPLNIA AQPGKTRLRK SLKLWQVVMM GLAYLTPMTV FDTFGIVSGI SDGHVPASYL
70 80 90 100 110 120
LALAGVLFTA ISYGKLVRQF PEAGSAYTYA QKSINPHVGF MVGWSSLLDY LFLPMINVLL
130 140 150 160 170 180
AKIYLSALFP EVPPWVWVVT FVAILTAANL KSVNLVANFN TLFVLVQISI MVVFIFLVVQ
190 200 210 220 230 240
GLHKGEGVGT VWSLQPFISE NAHLIPIITG ATIVCFSFLG FDAVTTLSEE TPDAARVIPK
250 260 270 280 290 300
AIFLTAVYGG VIFIAASFFM QLFFPDISRF KDPDAALPEI ALYVGGKLFQ SIFLCTTFVN
310 320 330 340 350 360
TLASGLASHA SVSRLLYVMG RDNVFPERVF GYVHPKWRTP ALNVIMVGIV ALSALFFDLV
370 380 390 400 410 420
TATALINFGA LVAFTFVNLS VFNHFWRRKG MNKSWKDHFH YLLMPLVGAL TVGVLWVNLE
430 440 450 460
STSLTLGLVW ASLGGAYLWY LIRRYRKVPL YDGDRTPVSE T