P75966

PR
Gene name
rluE (ymfC, b1135, JW1121)
Protein name
Ribosomal large subunit pseudouridine synthase E
Names
rRNA pseudouridylate synthase E, rRNA-uridine isomerase E
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1135
EC number
5.4.99.20: Transferring other groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-64 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P75966

Entry ID Method Resolution Chain Position Source
2OLW X-ray 160 A A/B 1-217 PDB
2OML X-ray 120 A A 29-217 PDB
AF-P75966-F1 Predicted AlphaFoldDB

No variants for P75966

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P75966

No associated diseases with P75966

2 regional properties for P75966

Type Name Position InterPro Accession
domain Pseudouridine synthase, RsuA/RluA-like 41 - 186 IPR006145
conserved_site Pseudouridine synthase, RsuA/RluB/E/F, conserved site 76 - 90 IPR018496

Functions

Description
EC Number 5.4.99.20 Transferring other groups
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
pseudouridine synthase activity Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.
RNA binding Binding to an RNA molecule or a portion thereof.
rRNA pseudouridine synthase activity Catalysis of the reaction: an rRNA uridine = an rRNA pseudouridine. Conversion of uridine in an rRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5.

1 GO annotations of biological process

Name Definition
enzyme-directed rRNA pseudouridine synthesis The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MRQFIISENT MQKTSFRNHQ VKRFSSQRST RRKPENQPTR VILFNKPYDV LPQFTDEAGR
70 80 90 100 110 120
KTLKEFIPVQ GVYAAGRLDR DSEGLLVLTN NGALQARLTQ PGKRTGKIYY VQVEGIPTQD
130 140 150 160 170 180
ALEALRNGVT LNDGPTLPAG AELVDEPAWL WPRNPPIRER KSIPTSWLKI TLYEGRNRQV
190 200 210
RRMTAHVGFP TLRLIRYAMG DYSLDNLANG EWREVTD