P75096

PR
Gene name
folD
Protein name
Bifunctional protein FolD
Names
Species
Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (Mycoplasmoides pneumoniae)
KEGG Pathway
mpn:MPN_017
EC number
1.5.1.5: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P75096

Entry ID Method Resolution Chain Position Source
AF-P75096-F1 Predicted AlphaFoldDB

No variants for P75096

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P75096

No associated diseases with P75096

4 regional properties for P75096

Type Name Position InterPro Accession
domain Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain 4 - 111 IPR020630
domain Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain 121 - 264 IPR020631
conserved_site Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site 66 - 91 IPR020867-1
conserved_site Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site 243 - 251 IPR020867-2

Functions

Description
EC Number 1.5.1.5 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

2 GO annotations of molecular function

Name Definition
methenyltetrahydrofolate cyclohydrolase activity Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate.
methylenetetrahydrofolate dehydrogenase (NADP+) activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH.

4 GO annotations of biological process

Name Definition
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
purine nucleotide biosynthetic process The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.
tetrahydrofolate interconversion The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSFDGKQLAH EILLTYKNRD WSQVKLVILQ TNNDVSSDAF IRQKMNACNT LGAQSELIKY
70 80 90 100 110 120
HESVTEKELL EKIQQLNTDP EVTGIILQLP VYPHLKQNKL LKAIDPYKDV DYLTGNCPLP
130 140 150 160 170 180
IRSCVVEAVL ILKEHFHHDF TNKQIVVVGL GVTGGGPIFH YLKETGHQVV GCDKHTPNTM
190 200 210 220 230 240
ELIKTADVVI TAIGKPHFFK TTNFKPGVIL YDVGVSRNVL NKLCGDIDPN GIEKVAKWWS
250 260
PTPGGVGPFT VLAIMKNLWV LYEAHQRRI