P75080
Gene name |
polC |
Protein name |
DNA polymerase III PolC-type |
Names |
PolIII |
Species |
Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (Mycoplasmoides pneumoniae) |
KEGG Pathway |
mpn:MPN_034 |
EC number |
2.7.7.7: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P75080
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P75080-F1 | Predicted | AlphaFoldDB |
No variants for P75080
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P75080 | |||||
No associated diseases with P75080
7 regional properties for P75080
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Polymerase/histidinol phosphatase, N-terminal | 322 - 389 | IPR003141 |
| domain | PHP domain | 323 - 681 | IPR004013 |
| domain | DNA polymerase III epsilon subunit, exonuclease domain | 403 - 604 | IPR006054 |
| domain | Bacterial DNA polymerase III, alpha subunit, NTPase domain | 826 - 1097 | IPR011708 |
| domain | Exonuclease, RNase T/DNA polymerase III | 407 - 576 | IPR013520 |
| domain | DNA polymerase, helix-hairpin-helix motif | 1354 - 1436 | IPR029460 |
| domain | DNA polymerase III alpha subunit finger domain | 1101 - 1240 | IPR040982 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.7 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| 3'-5' exonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. |
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA-templated DNA replication | A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVFDTETEKG | KRIWALSQFL | VKKNILDHNE | LHQLNNRIEL | VYLENDRENA | LFLVALTLKK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| PLTIDIWNAL | YEGFQDAEGA | ELRITFQEDA | TFFKDGSTKS | SVTLAIIKDY | FKSFFGKDKK |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YRILLEQELT | HPNFLSYSNH | ELKANCQSQE | LDQWLIEQRQ | AFIKWMHQAG | FTHFGFVSLF |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NPPAEKQLKV | KSMKVSKYDK | QFETEVFSTE | FVPIHKINQQ | MDEIKLMGQI | FELKDFPGYN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NLRNTLNIYV | TDFQLGGSLI | LKWFYKDPKT | IEGIKIGTWV | KATVKVERDA | KTQLLQGIIK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EISPIETPAY | YRRPDQDKQK | RVELVFHTKM | SAFDGINSVQ | EYAQFAKERD | WKTIAVTDKD |
| 370 | 380 | 390 | 400 | 410 | 420 |
| NIHIYPTLYE | VAKKYGLKAI | YGLECNLIDD | HIKIVSNPDK | TKLKDATFVI | FDIETTGLHG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| RYDSVIEFAG | IKVKHNREVE | RMQFFLKIDG | PLPAAVTEIT | KITQAQLEDG | MEQQAGLEKL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| RAWLDGCVMV | AHNGLSFDLP | FLQTQFEKYN | IAPLTNPLID | TLALSWALNP | GFASHTLSNI |
| 550 | 560 | 570 | 580 | 590 | 600 |
| CAKLKFDFDD | ERLHRADYDT | QALKKVFDYF | KEQVELMGIT | NLEQLDQELN | QQCHFELLKR |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TFTNTGIIYI | KSQSGFAKLY | ELLSIALTDN | NATRPLVLTS | TLQKFAKSFV | ITDNPVQGDI |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FKAALTKPLK | ELEAAIKRVD | FVLIAPPGAY | AGYTIREGLK | KEAIPNAIKL | VVDTAQRLNK |
| 730 | 740 | 750 | 760 | 770 | 780 |
| LVAVASDAYF | IHPWENEYYK | AIVCAKGLGG | RWHRHFNYKE | REQRVPNVFV | RTTGEMLNEM |
| 790 | 800 | 810 | 820 | 830 | 840 |
| SFLGEQLAYE | LVVENTNKLA | KQLTADDLVP | VQTKLQPPVI | EGSNENLAAK | TWSQAKAIYG |
| 850 | 860 | 870 | 880 | 890 | 900 |
| DPLPKLIEQR | IQEELKAIID | NGFGIIYWIS | HLLVKQSVQD | GYFVGPRGSI | GSSLVANLIG |
| 910 | 920 | 930 | 940 | 950 | 960 |
| ISEINPLVPH | YLCESCQYFE | VNEEVDDGYD | LMVRDCPKCG | AKAAFKGDGH | NIPFATFMGF |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| AGDKIPDIDL | NFSSEYQAKA | HAYVRELFGE | QYTFRAGTIA | TVAEKTAYGY | ARNYFEIIKQ |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| TELATAPEIE | RFKQKLVGIK | RTTGQHPGGI | MIFPNHKSVY | EFTPCGYPAD | DTSSDWKTTH |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| FEYDALGNTI | LKLDILGQDD | PTMLKHLGDL | THVNPQNIPR | FDKKLTEMFW | SVNPLKLKPH |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| YLDEPTGAIG | IPEFGTKFVR | KILEQTKPKG | FGDLIRVSGL | SHGKNVWADN | AQKILKDQNL |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| SLKDVIACRD | DIMLYLIHKG | MQAKDAFEIM | EKVRKGIALN | AKEVQLMQSN | GVEQHWINSC |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| LKISYLFPKA | HAAAYVLMAW | RIAWFKLYHP | LSYYACLLSF | KLKEHDVSGF | KSGVSFVKQK |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| LEELNTLYRI | KRIKPKEAEL | LTSYEVYLEM | MARGIKLEQI | SLTHSHATRF | VEHNGMLIAP |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| FITIPGMGEA | VANSIIEARN | EKPFSSLDDF | KKRTKITKKH | IEAFTQMQLL | DEFREQDNQK |
| KLF |