P74918

PR
Gene name
pol
Protein name
DNA polymerase
Names
Pol Tfu
Species
Thermococcus fumicolans
KEGG Pathway
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1390-1469 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P74918

Entry ID Method Resolution Chain Position Source
AF-P74918-F1 Predicted AlphaFoldDB

No variants for P74918

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P74918

No associated diseases with P74918

22 regional properties for P74918

Type Name Position InterPro Accession
domain Hint domain C-terminal 727 - 772 IPR003586-1
domain Hint domain C-terminal 1252 - 1295 IPR003586-2
domain Hint domain N-terminal 405 - 495 IPR003587-1
domain Hint domain N-terminal 899 - 1015 IPR003587-2
domain Intein DOD homing endonuclease 524 - 665 IPR004042-1
domain Intein DOD homing endonuclease 1047 - 1186 IPR004042-2
domain Homing endonuclease, LAGLIDADG 623 - 698 IPR004860-1
domain Homing endonuclease, LAGLIDADG 1139 - 1224 IPR004860-2
domain DNA-directed DNA polymerase, family B, exonuclease domain 22 - 129 IPR006133-1
domain DNA-directed DNA polymerase, family B, exonuclease domain 130 - 278 IPR006133-2
domain DNA-directed DNA polymerase, family B, multifunctional domain 680 - 891 IPR006134-1
domain DNA-directed DNA polymerase, family B, multifunctional domain 1290 - 1496 IPR006134-2
ptm Intein N-terminal splicing region 407 - 470 IPR006141-1
ptm Intein N-terminal splicing region 901 - 992 IPR006141-2
domain Intein 457 - 470 IPR006142-1
domain Intein 1044 - 1056 IPR006142-2
domain Intein 1143 - 1155 IPR006142-3
domain Intein 1173 - 1188 IPR006142-4
domain Intein 1266 - 1283 IPR006142-5
domain Intein 1284 - 1293 IPR006142-6
domain Intein C-terminal splicing region 745 - 767 IPR030934-1
domain Intein C-terminal splicing region 1268 - 1290 IPR030934-2

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.

3 GO annotations of biological process

Name Definition
DNA replication The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
intein-mediated protein splicing The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues.
intron homing Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MILDTDYITE DGRPVIRVFK KENGEFKIEY DRDFEPYIYA LLKDDSAIED VKKITASRHG
70 80 90 100 110 120
TTVRVVRAGK VKKKFLGRPI EVWKLYFTHP QDVPAIRDKI REHPAVVDIY EYDIPFAKRY
130 140 150 160 170 180
LIDKGLIPME GDEELKMLAF DIETLYHEGE EFAEGPILMI SYADEEGARV ITWKKIDLPY
190 200 210 220 230 240
VDVVSTEKEM IKRFLKVVKE KDPDVLITYN GDNFDFAYLK KRSEKLGVKF ILGRDGSEPK
250 260 270 280 290 300
IQRMGDRFAV EVKGRIHFDL YPVIRHTINL PTYTLEAVYE AIFGQPKEKV YAEEIAQAWE
310 320 330 340 350 360
TGEGLERVAR YSMEDAKVTY ELGREFFPME AQLSRLVGQS FWDVSRSSTG NLVEWYLLRK
370 380 390 400 410 420
AYERNELAPN KPSGRELERR RGGYAGGYVK EPERGLWENI AYLDFRCHPA DTKVIVKGKG
430 440 450 460 470 480
VVNISEVREG DYVLGIDGWQ KVQRVWEYDY EGELVNINGL KCTPNHKLPV VRRTERQTAI
490 500 510 520 530 540
RDSLAKSFLT KKVKGKLITT PLFEKIGKIE REDVPEEEIL KGELAGIILA EGTLLRKDVE
550 560 570 580 590 600
YFDSSRGKKR VSHQYRVEIT VGAQEEDFQR RIVYIFERLF GVTPSVYRKK NTNAITFKVA
610 620 630 640 650 660
KKEVYLRVRE IMDGIENLHA PSVLRGFFEG DGSVNKVRKT VVVNQGTNNE WKIEVVSKLL
670 680 690 700 710 720
NKLGIPHRRY TYDYTEREKT MTTHILEIAG RDGLILFQTI VGFISTEKNM ALEEAIRNRE
730 740 750 760 770 780
VNRLENNAFY TLADFTAKTE YYKGKVYDLT LEGTPYYFAN GILTHNSLYP SIIISHNVSP
790 800 810 820 830 840
DTLNREGCGE YDEAPQVGHR FCKDFPGFIP SLLGDLLDER QKVKKHMKAT VDPIEKKLLD
850 860 870 880 890 900
YRQRAIKILA NSFYGYYGYA KARWYCKECA ESVTAWGRQY IETTMREIEE KFGFKVLYAD
910 920 930 940 950 960
SVTGDTEVTI RRNGRIEFVP IEKLFERVDH RVGEKEYCVL GGVEALTLDN RGRLVWKKVP
970 980 990 1000 1010 1020
YVMRHKTDKR IYRVWFTNSW YLDVTEDHSL IGYLNTSKVK PGKPLKERLV EVKPEELGGK
1030 1040 1050 1060 1070 1080
VKSLITPNRP IARTIKANPI AVKLWELIGL LVGDGNWGGQ SNWAKYYVGL SCGLDKAEIE
1090 1100 1110 1120 1130 1140
RKVLNPLREA SVISNYYDKS KKGDVSILSK WLAGFMVKYF KDENGNKAIP SFMFNLPREY
1150 1160 1170 1180 1190 1200
IEAFLRGLFS ADGTVSLRRG IPEIRLTSVN RELSDAVRKL LWLVGVSNSL FTETKPNRYL
1210 1220 1230 1240 1250 1260
EKESGTHSIH VRIKNKHRFA DRIGFLIDRK STKLSENLGG HTNKKRAYKY DFDLVYPRKI
1270 1280 1290 1300 1310 1320
EEITYDGYVY DIEVEGTHRF FANGILVHNT DGFFATIPGA DAETVKKKAR EFLNYINPKL
1330 1340 1350 1360 1370 1380
PGLLELEYEG FYRRGFFVTK KKYAVIDEEG KITTRGLEIV RRDWSEVAKE TQARVLEAIL
1390 1400 1410 1420 1430 1440
RHGDVEEAVR IVKEVTEKLS KYEVPPEKLV IHEQITRELK DYKATGPHVA IAKRLAARGI
1450 1460 1470 1480 1490 1500
KVRPGTVISY IVLKGSGRIG DRTIPFDEFD PTKHRYDAEY YIENQVLPAV ERILKAFGYK
1510 1520
KEDLRYQKTR QVGLGAWLKM GKK