P74876

PR
Gene name
dnaX (dnaZ, dnaZX, STM0484)
Protein name
DNA polymerase III subunit tau
Names
DNA polymerase III subunit gamma
Species
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
KEGG Pathway
stm:STM0484
EC number
2.7.7.7: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

339-532 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P74876

Entry ID Method Resolution Chain Position Source
AF-P74876-F1 Predicted AlphaFoldDB

No variants for P74876

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P74876

No associated diseases with P74876

No regional properties for P74876

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P74876

Functions

Description
EC Number 2.7.7.7 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
DNA polymerase III complex The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group.

1 GO annotations of biological process

Name Definition
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSYQVLARKW RPQTFADVVG QEHVLTALAN GLSLGRIHHA YLFSGTRGVG KTSIARLLAK
70 80 90 100 110 120
GLNCETGITA TPCGVCDNCR EIEQGRFVDL IEIDAASRTK VEDTRDLLDN VQYAPARGRF
130 140 150 160 170 180
KVYLIDEVHM LSRHSFNALL KTLEEPPAHV KFLLATTDPQ KLPVTILSRC LQFHLKALDV
190 200 210 220 230 240
EQIRHQLEHI LNEEHIAHEP RALQLLSRAA DGSLRDALSL TDQAIASGDG QVSTQAVSAM
250 260 270 280 290 300
LGTLDDDQAL SLVEAVVDAN GERVMSLINE AAARGIEWEA LLVEMLSLLH RIAMVQLSPA
310 320 330 340 350 360
ALGSDMAAIE QRMRELARTV PPGDLQLYYQ TLLIGRKELP WAPDRRMGVE MTLLRALAFH
370 380 390 400 410 420
PRMPLPEPET PRQSFAPVAP TAVMTPPQLQ QPSAPAPQTS PAPLPASTSQ VLAARNQLQR
430 440 450 460 470 480
AQGVTKTKKS EPAAASRARP VNNSALERLA SVSERVQARP APSALETAPV KKEAYRWKAT
490 500 510 520 530 540
TPVVQTKEVV ATPKALKKAL EHEKTPELAA KLAAEAIERD PWAAQVSQLS LPKLVEQVAL
550 560 570 580 590 600
NAWKEQNGNA VCLHLRSTQR HLNSSGAQQK LAQALSDLTG TTVELTIVED DNPAVRTPLE
610 620 630 640
WRQAIYEEKL AQARESIIAD NNIQTLRRFF DAELDEESIR PI