P74587

PR
Gene name
carA
Protein name
Carbamoyl-phosphate synthase small chain
Names
Carbamoyl-phosphate synthetase glutamine chain
Species
Synechocystis sp (strain PCC 6803 / Kazusa)
KEGG Pathway
syn:sll1498
EC number
6.3.5.5: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

42-112 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P74587

Entry ID Method Resolution Chain Position Source
AF-P74587-F1 Predicted AlphaFoldDB

No variants for P74587

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P74587

No associated diseases with P74587

3 regional properties for P74587

Type Name Position InterPro Accession
domain Carbamoyl-phosphate synthase small subunit, N-terminal domain 7 - 137 IPR002474
domain Glutamine amidotransferase 199 - 373 IPR017926
domain Carbamoyl-phosphate synthase small subunit, GATase1 domain 197 - 372 IPR035686

Functions

Description
EC Number 6.3.5.5 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
carbamoyl-phosphate synthase complex A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate.

5 GO annotations of biological process

Name Definition
'de novo' pyrimidine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
'de novo' UMP biosynthetic process The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen.
arginine biosynthetic process The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid.
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
nitrogen compound metabolic process The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPIAAAKPAL LVLADGTPYP GWSFGADGTT VGEVVFNTGM TGYQEVMTDP SYCGQIVTFT
70 80 90 100 110 120
YPELGNTGVN AEDEESIHPH VKGVVARNIT RRPSNWRSTQ SLPDYLVEHK IIGIYGIDTR
130 140 150 160 170 180
ALTRKLRSIG AMNGGISTEI LEPEALLHHI QAAPSMAGLN LVKEVTTHEV YEWTDSTNDH
190 200 210 220 230 240
WQFGPVAEQQ GQPPLTVVAL DFGVKRNILR RLASYGCRVI VVPASTSAAE ILQYNPDGIF
250 260 270 280 290 300
LSNGPGDPSA VEEGIVTTKE LLAAKKPMFG ICMGHQVLGL SLGAETFKLK FGHRGLNQPC
310 320 330 340 350 360
GLEQQVEITS QNHGFAVTEG SLAEEVEITH FNLNDKTVAG LRHKELPFFS VQYHPEASPG
370 380
PHDADYLFEK FVKLMRQQKA EVAG