P74292
Gene name |
nadE |
Protein name |
Glutamine-dependent NAD(+) synthetase |
Names |
NAD(+) synthase [glutamine-hydrolyzing] |
Species |
Synechocystis sp (strain PCC 6803 / Kazusa) |
KEGG Pathway |
syn:slr1691 |
EC number |
6.3.5.1: Carbon--nitrogen ligases with glutamine as amido-N-donor |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P74292
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P74292-F1 | Predicted | AlphaFoldDB |
No variants for P74292
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P74292 | |||||
No associated diseases with P74292
No regional properties for P74292
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P74292 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.5.1 | Carbon--nitrogen ligases with glutamine as amido-N-donor |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| glutaminase activity | Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3. |
| NAD+ synthase (glutamine-hydrolyzing) activity | Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate. |
| NAD+ synthase activity | Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| NAD biosynthetic process | The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MFTIALAQLN | PTIGAIAENA | EKIVTAALQA | QARGADLLLT | PELALCGYPP | KDLLLNPSFV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EQLEEELQWL | AEKMPPSIAI | LVGTVTPHHQ | AERQGQKKLW | NSAVLIEQGQ | IKQWFHKCLL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PTYDVFDEDR | YFASAAKSEY | FIYKNVKIGV | TICEDLWNDE | AFWGQKFYQV | NPLMDLIDQG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VNLVVNLSAS | PYSCGKHYLR | ESLISHSAKR | FNVPLIYVNQ | VGGNDDLIFD | GGSFAVNSQG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KIIGRSPLFQ | EDLALLSYDL | SSGELTGQKL | ASLPMVDTEE | LWQALVLGVG | DYLHKCGFSK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| AILGLSGGID | SSLVAAIAVE | ALGKENVLGI | LMPSPYSSDH | SIQDALALAK | NLGMNTQTIP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| IGPIMATYDQ | ALVPLFQDAP | FGLAEENLQS | RIRGNLLMAI | ANKFGHLLLS | TGNKSELAVG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YCTLYGDMNG | GLAAIADVPK | TQVFELCRWL | NREQTIIPPS | VLTKPPSAEL | KPGQVDTDSL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PPYDVLDGIL | GRLVEKHQSP | QEIINAGFER | EVVLKICQLV | QKSEFKRRQA | APGLKVTDRA |
| 550 | |||||
| FGSGWRMPIA | QAFHPQGS |