P74181
Gene name |
ggt (slr1269) |
Protein name |
Glutathione hydrolase proenzyme |
Names |
Gamma-glutamyltranspeptidase proenzyme |
Species |
Synechocystis sp (strain PCC 6803 / Kazusa) |
KEGG Pathway |
syn:slr1269 |
EC number |
2.3.2.2: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P74181
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P74181-F1 | Predicted | AlphaFoldDB |
No variants for P74181
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P74181 | |||||
No associated diseases with P74181
No regional properties for P74181
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P74181 | |||
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.2 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| glutathione hydrolase activity | Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate. |
| hypoglycin A gamma-glutamyl transpeptidase activity | Catalysis of the reaction: glutathionate + hypoglycin A = L-cysteinylglycine + hypoglycin B. |
| leukotriene C4 gamma-glutamyl transferase activity | Catalysis of the reaction: leukotriene C4 + a standard alpha amino acid = leukotriene D4 + an (gamma-L-glutamyl)-L-amino acid. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| glutathione biosynthetic process | The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. |
| glutathione catabolic process | The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. |
| proteolysis | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAGKTTGVVA | AGHAQTAEAG | KCMLEEGGNA | FDAAIASVLA | ACVVESSLTS | LGGGGFLLAQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TAAKKSYLFD | FFCQTPQVNP | GEKAVDFYPV | ALNFGGAWQT | FHIGKGAIAV | PGMVAGLFAA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HRKLGQLPFK | VLIEPAVAYA | RQGFTLNRFN | DFTNGLLEPI | LTQQEEGRKF | YAPQGKILRQ |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GEKAYLPQFA | DVLEQLARHG | PDWFYRGELT | EWVLESLGEA | SALTAKDWAD | YQVEIRLPLR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| AQYRQRQLLT | NPPPSAGGIL | IAFALQLLEK | YDLSQYPLGS | AAQIQLFSQV | MALSNQARRQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YLDGNLHCGD | IEAKFLGGDR | LASELGQSKF | INKLGSTTHI | SVLDGEGNAA | SLTSSNGEGS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| GHFIPGTGIM | LNNMLGEEDL | NPQGFYQWPP | GQRLSSMMAP | TILLDQEQPR | LVLGSGGSNR |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IRSAILQVVC | HHLDYQLPLA | EAVGRERIHW | EAHKLDLEPT | SVADILAQLR | FDDGTQGTLW |
| 490 | 500 | 510 | |||
| TEQNMFFGGV | HGVATTTAGT | MEGVGDPRRS | GAVAYSLE |