P73274

PR
Gene name
leuS
Protein name
Leucine--tRNA ligase
Names
Leucyl-tRNA synthetase, LeuRS
Species
Synechocystis sp (strain PCC 6803 / Kazusa)
KEGG Pathway
syn:sll1074
EC number
6.1.1.4: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

572-650 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P73274

Entry ID Method Resolution Chain Position Source
AF-P73274-F1 Predicted AlphaFoldDB

No variants for P73274

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P73274

No associated diseases with P73274

6 regional properties for P73274

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 53 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 421 - 577 IPR002300-1
domain Aminoacyl-tRNA synthetase, class Ia 622 - 662 IPR002300-2
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 711 - 831 IPR013155
domain Methionyl/Leucyl tRNA synthetase 40 - 173 IPR015413
domain Leucyl-tRNA synthetase, editing domain 223 - 407 IPR025709

Functions

Description
EC Number 6.1.1.4 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
leucine-tRNA ligase activity Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu).

1 GO annotations of biological process

Name Definition
leucyl-tRNA aminoacylation The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASPYNAGEI EQKWQQRWAE WGLDKTPIAS DLPKFYALSM FPYPSGNLHM GHVRNYTITD
70 80 90 100 110 120
VIARLKRMQG YQVLHPMGWD AFGLPAENAA IERGIPPKQW TEKNIAQMRA QLQQLGLSID
130 140 150 160 170 180
WEREVATCAP DYYRWTQWLF LEFFQAGLAY QKEATVNWDP IDQTVLANEQ VDSEGRSWRS
190 200 210 220 230 240
GAMVERKLLR QWFLKITDYA EALLNDLEQL TGWPERVKLM QSHWIGKSVG AYLEFPIKDS
250 260 270 280 290 300
QEKIAVFTTR PDTVYGVTYV VLAPEHPLTK VVTTAEQQGT VDEFVAMVAK ESEIERTAED
310 320 330 340 350 360
KPKRGVKTGG IAINPFNGEE IPILIADYVL YEYGTGAVMG VPAHDQRDFK FAQDNNLPMQ
370 380 390 400 410 420
VVIIPDDADN SDVNLTVAYT EAGVMVNSAQ FTGMASPKAK QAIIKFAEDN DYGRAKVQYR
430 440 450 460 470 480
LRDWLISRQR YWGCPIPIIH CDDCGAVPVP TKDLPVELPD NVEFSGRGPS PLAKLEDWIN
490 500 510 520 530 540
VPCPSCGKPA RRETDTMDTF IDSSWYFLRY ADAQNTELPF DGEKVAHWLP VDQYVGGIEH
550 560 570 580 590 600
AILHLLYSRF FTKVLADRQL IPVKEPFQKL LTQGMVQGIT YKNPTTGKYV PAKDLQTGQQ
610 620 630 640 650 660
VIDPKDPKDP DSGEPLQVFY EKMSKSKFNG VDPQEVLAKY GADTARMFIL FKAPPEKDLE
670 680 690 700 710 720
WDDADVEGQF RFLNRVWRLV TDYIGDPAGI RFAVRPETLV TNEPLTKAEK DLRRAIHGAI
730 740 750 760 770 780
KEVAEDLNDD YQFNTAISEM MKLSNALIAA TDLISFPVYQ EGIETLLLLL APFAPHLTEE
790 800 810 820 830 840
LWHRLGRTDS IHQQAWLQVD PTALVLDEIT LVIQVLGKTR GTITVPASAD KTQLEELARN
850 860
SDLAQRYLEG KTIKKVIVVP GKLVNFVIT