P71319

PR
Gene name
metF
Protein name
5,10-methylenetetrahydrofolate reductase
Names
Species
Pectobacterium carotovorum subsp. carotovorum (Erwinia carotovora subsp. carotovora)
KEGG Pathway
EC number
1.5.1.54: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-78 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P71319

Entry ID Method Resolution Chain Position Source
AF-P71319-F1 Predicted AlphaFoldDB

No variants for P71319

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P71319

No associated diseases with P71319

No regional properties for P71319

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P71319

Functions

Description
EC Number 1.5.1.54 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
methylenetetrahydrofolate reductase NADH activity Catalysis of the reaction: 5-methyltetrahydrofolate + NAD + = 5,10-methylenetetrahydrofolate + NADH + H+.
methylenetetrahydrofolate reductase NADPH activity Catalysis of the reaction: 5-methyltetrahydrofolate + NADP + = 5,10-methylenetetrahydrofolate + NADPH + H+.

2 GO annotations of biological process

Name Definition
methionine biosynthetic process The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
tetrahydrofolate interconversion The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSFFHANQRE ALNQSLAELQ GRINVSFEFF PPRTSDMEET LWSSIDRLSS LKPKFVSVTY
70 80 90 100 110 120
GANSGERDRT HSIIKTIKER TGLEAAPHLT CIDASREQLR EIAQDYWESG IRHIVALRGD
130 140 150 160 170 180
LPQEGGKPDM YAADLVSLLK EVGDFDISVA AYPEVHPEAK SAQADLINLK HKIDAGANRA
190 200 210 220 230 240
ITQFFFDVES YLRFRDRCVA TGIDVEIVPG ILPVSNFKQL QKFATMTNVR VPNWMTTMFD
250 260 270 280 290
GLDNDPETRK MVGASIAMDM VKILSREGVK DFHFYTLNRA ELSYAICHTL GVRPDVAR