P70973
Gene name |
truA |
Protein name |
tRNA pseudouridine synthase A |
Names |
tRNA pseudouridine(38-40) synthase, tRNA pseudouridylate synthase I, tRNA-uridine isomerase I |
Species |
Bacillus subtilis (strain 168) |
KEGG Pathway |
bsu:BSU01480 |
EC number |
5.4.99.12: Transferring other groups |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P70973
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P70973-F1 | Predicted | AlphaFoldDB |
No variants for P70973
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P70973 | |||||
No associated diseases with P70973
2 regional properties for P70973
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Pseudouridine synthase I, TruA, alpha/beta domain | 9 - 104 | IPR020097-1 |
| domain | Pseudouridine synthase I, TruA, alpha/beta domain | 144 - 246 | IPR020097-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 5.4.99.12 | Transferring other groups |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| pseudouridine synthase activity | Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| tRNA pseudouridine synthase activity | Catalysis of the reaction: tRNA uridine = tRNA pseudouridine. Conversion of uridine in a tRNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tRNA pseudouridine synthesis | The intramolecular conversion of uridine to pseudouridine in a tRNA molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRLKCTISYD | GHLFNGYQVQ | PGKRTVQDEL | EKALAVLHKS | KDRIPVVSSG | RTDSGVHAAG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QVIHFDTPLS | IPAERWPYAL | NALLPDDIAV | KQAEIADDGF | HARFSAVKKE | YRYFVYTEKH |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PDVFKRHYAY | HFSYRLNVQD | MREAAKHLIG | THDFTSFCAA | KTEVQDKVRT | IYELDWTETA |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DGLQMRITGS | GFLYNMVRII | AGTLLDAGIG | KISPDEVKSM | LEAKDREAAG | RTAPGHGLYL |
| WNVYYDN |