Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P70755
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P70755-F1 | Predicted | AlphaFoldDB |
No variants for P70755
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P70755 | |||||
No associated diseases with P70755
5 regional properties for P70755
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | DNA mismatch repair protein MutS, C-terminal | 600 - 790 | IPR000432 |
| domain | DNA mismatch repair protein MutS-like, N-terminal | 9 - 121 | IPR007695 |
| domain | DNA mismatch repair protein MutS, core | 264 - 585 | IPR007696 |
| domain | DNA mismatch repair protein MutS, connector domain | 126 - 243 | IPR007860 |
| domain | DNA mismatch repair protein MutS, clamp | 422 - 513 | IPR007861 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP-dependent DNA damage sensor activity | A molecule that recognises toxic DNA structures, and initiates a signalling response, driven by ATP hydrolysis. |
| damaged DNA binding | Binding to damaged DNA. |
| mismatched DNA binding | Binding to a double-stranded DNA region containing one or more mismatches. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| mismatch repair | A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGKEEKELTP | MLAQYHQFKS | MYPDCLLLFR | LGDFYELFYE | DAVVGSKELG | LVLTSRPAGK |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GRERIPMCGV | PYHSANNYIA | KLVNKGYKVA | ICEQVEDPSK | AKGIVKRDVI | RVITPGTFFE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RETGGLCSLY | RKGKSYLVSY | LNLSVGEFIG | AKVKEEELID | FLSKFNIREV | LVKKGEKLPE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KLEKVLKLHI | TELEEEFFEE | GKEELLKDYG | VPSIKAFGFQ | DEDLSLSLGA | VYRYAKATQK |
| 250 | 260 | 270 | 280 | 290 | 300 |
| SFTPLIPKPK | PYVDEGYVKL | DLKAVKGLEI | TESIEGRKDL | SLFKVVDRTL | TGMGRRRLRF |
| 310 | 320 | 330 | 340 | 350 | 360 |
| RLLNPFRSIE | RIRKVQEAVE | ELINKREVLN | EIRKTLEGMS | DLERLVSRIS | SNMASPRELI |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HLKNSLRKAE | ELRKILSLLD | SEIFKEIEGS | LLNLNKVADL | IDKTLVDDPP | LHVKEGGLIK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| PGVNAYLDEL | RFIRENAEKL | LKEYEKKLKK | ETGIQSLKIG | YNKVMGYYIE | VTKANVKYVP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EHFRRRQTLS | NAERYTTEEL | QRLEEKILSA | QTRINELEYE | LYRELREEVV | KELDKVGNNA |
| 550 | 560 | 570 | 580 | 590 | 600 |
| TLIGEVDYIQ | SLAWLALEKG | WVKPEVHEGY | ELIIEEGKHP | VIEEFTKNYV | PNDTKLTEEE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| FIHVITGPNM | AGKSSYIRQV | GVLTLLAHTG | SFLPVKSARI | PLVDAIFTRI | GSGDVLALGV |
| 670 | 680 | 690 | 700 | 710 | 720 |
| STFMNEMLDV | SNILNNATKR | SLIILDEVGR | GTSTYDGIAI | SKAIVKYISE | KIGAKTLLAT |
| 730 | 740 | 750 | 760 | 770 | 780 |
| HYLELTELER | KVKGVKNYHM | EVEETDEGIR | FLYILKEGRA | KGSFGIDVAK | LAGLPEEVVR |
| 790 | 800 | 810 | 820 | 830 | 840 |
| EAKKILKELE | GEKGKQEVLP | FLEETYKKSV | DEEKLNFYEE | IIKEIEEIDI | GNTTPVKALL |
| 850 | |||||
| ILAELKERIK | SFIKR |