Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P70114
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P70114-F1 | Predicted | AlphaFoldDB |
No variants for P70114
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P70114 | |||||
No associated diseases with P70114
No regional properties for P70114
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P70114 | |||
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cholesterol binding | Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| cholesterol transfer activity | Removes cholesterol from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| cellular lipid metabolic process | The chemical reactions and pathways involving lipids, as carried out by individual cells. |
| cholesterol metabolic process | The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. |
| glucocorticoid metabolic process | The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. |
| positive regulation of bile acid biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of bile acids. |
| steroid biosynthetic process | The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MLLATFKLCA | GSSYRHLRNM | KGLRHQAVLA | IGQELNRRTL | GDSSPGWISQ | VRRRSSLLGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| QLEAALYSEQ | ELSYIQQGEV | AMQKALSILS | NQEGWKKENQ | QENGDEVLSK | VVPDVGKVFR |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LEVVVDQPMD | RLYAELVDRM | EAMGEWNPNV | KEIKVLQKIG | KDTVITHELA | AAAAGNLVGP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RDFVSVRCAK | RRGSTCVLAG | IATHFGEMPE | QSGVIRAEQG | PTCMVLHPLA | GSPSKTKFTW |
| 250 | 260 | 270 | 280 | ||
| LLSIDLKGWL | PKSIINQVLS | QTQMEFANHL | RKRLESSSAS | EARC |