P70085

PR
Gene name
cyp17a1 (cyp17)
Protein name
Steroid 17-alpha-hydroxylase/17,20 lyase
Names
17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17
Species
Oryzias latipes (Japanese rice fish) (Japanese killifish)
KEGG Pathway
ola:100125816
EC number
1.14.14.19: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-138 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P70085

Entry ID Method Resolution Chain Position Source
AF-P70085-F1 Predicted AlphaFoldDB

No variants for P70085

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P70085

No associated diseases with P70085

1 regional properties for P70085

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 444 - 453 IPR017972

Functions

Description
EC Number 1.14.14.19 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name Definition
17-alpha-hydroxyprogesterone aldolase activity Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
steroid 17-alpha-monooxygenase activity Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.

4 GO annotations of biological process

Name Definition
hormone biosynthetic process The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone.
progesterone metabolic process The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.
sex differentiation The establishment of the sex of an organism by physical differentiation.
steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAWFLCLSVL VVLVLALAAL LWRVRTRDRP QEAPSLPYLP VLGSLLSLRS PHPPHVLFKE
70 80 90 100 110 120
LQQKYGQTYS LKMGSHQVII VNHHAHAREV LLKRGRTFAG RPRTVTTDVL TRDGKDIAFG
130 140 150 160 170 180
DYSATWRFHR KIVHGALCMF GEGSASLQRI ICTEAQSLCS TLSEAAATGL ALDLSPELTR
190 200 210 220 230 240
AVTNVICSLC FNSSYSRGDP EFEAMLRYSQ GIVDTVAKDS LVDIFPWLQI FPNKDLRLLK
250 260 270 280 290 300
QCVAVRDQLL QKKFEEHKSD YSDHVQRDLL DALLRAKRSA ENNNTAAEFS AEAVGLSDDH
310 320 330 340 350 360
LLMTVGDIFG AGVETTTTVL KWAITYLIHY PEVQKQIQEE LDRKVGVDRP PQLSDRGSLP
370 380 390 400 410 420
FLEATIREVL RIRPVAPLLI PHVALSDTSL GDFTVRKGTR VVINLWSLHH DEKEWTNPDL
430 440 450 460 470 480
FNPGRFLSAD GSSLTLPSSS YLPFGAGLRV CLGEALAKME LFLFLSWILQ RFTLSVPPSQ
490 500 510
SLPSLEGKFG VVLQPVKYAV KATPRPGCHS GLFPANP