P69797

PR
Gene name
manX
Protein name
PTS system mannose-specific EIIAB component
Names
EIIAB-Man, EIII-Man
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b1817
EC number
2.7.1.191: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

104-179 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for P69797

Entry ID Method Resolution Chain Position Source
1PDO X-ray 170 A A 2-133 PDB
1VRC NMR - A/B 1-133 PDB
1VSQ NMR - PDB
2JZH NMR - A 154-323 PDB
2JZN NMR - PDB
2JZO NMR - PDB
AF-P69797-F1 Predicted AlphaFoldDB

No variants for P69797

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P69797

No associated diseases with P69797

4 regional properties for P69797

Type Name Position InterPro Accession
domain Phosphotransferase system, mannose-type IIA component 2 - 126 IPR004701
domain Phosphotransferase system, sorbose subfamily IIB component 160 - 323 IPR004720
domain Phosphotransferase system, mannose family IIA component 2 - 117 IPR013789
domain PTS system mannose/sorbose specific IIA subunit 3 - 124 IPR033887

Functions

Description
EC Number 2.7.1.191 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Cytoplasm
  • Cell inner membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
transmembrane transporter complex A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other.

2 GO annotations of molecular function

Name Definition
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.

4 GO annotations of biological process

Name Definition
glucose import across plasma membrane The directed movement of glucose from outside of a cell, across the plasma membrane and into the cytosol.
mannose transmembrane transport The process in which mannose is transported across a lipid bilayer, from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins.
phosphoenolpyruvate-dependent sugar phosphotransferase system The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTIAIVIGTH GWAAEQLLKT AEMLLGEQEN VGWIDFVPGE NAETLIEKYN AQLAKLDTTK
70 80 90 100 110 120
GVLFLVDTWG GSPFNAASRI VVDKEHYEVI AGVNIPMLVE TLMARDDDPS FDELVALAVE
130 140 150 160 170 180
TGREGVKALK AKPVEKAAPA PAAAAPKAAP TPAKPMGPND YMVIGLARID DRLIHGQVAT
190 200 210 220 230 240
RWTKETNVSR IIVVSDEVAA DTVRKTLLTQ VAPPGVTAHV VDVAKMIRVY NNPKYAGERV
250 260 270 280 290 300
MLLFTNPTDV ERLVEGGVKI TSVNVGGMAF RQGKTQVNNA VSVDEKDIEA FKKLNARGIE
310 320
LEVRKVSTDP KLKMMDLISK IDK