P68339
Gene name |
UL41 |
Protein name |
Virion host shutoff protein |
Names |
Vhs |
Species |
Human herpesvirus 2 (strain G) (HHV-2) (Human herpes simplex virus 2) |
KEGG Pathway |
vg:1487328 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
0 structures for P68339
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|
No variants for P68339
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P68339 | |||||
No associated diseases with P68339
1 regional properties for P68339
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | XPG-I domain | 193 - 229 | IPR006086 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| virion component | Any constituent part of a virion, a complete fully infectious extracellular virus particle. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| induction by virus of catabolism of host mRNA | The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA). |
| mitigation of host antiviral defense response | A process by which a virus avoids or tolerates the effects of its host organism's defenses. Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction. |
| suppression by virus of host gene expression | Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGLFGMMKFA | QTHHLVKRRG | LRAPEGYFTP | IAVDLWNVMY | TLVVKYQRRY | PSYDREAITL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HCLCSMLRVF | TQKSLFPIFV | TDRGVECTEP | VVFGAKAILA | RTTAQCRTDE | EASDVDASPP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PSPITDSRPS | FAFSNMRRRG | HAFAPGDRGT | RAAGPGPAAP | SGAPSKPALR | LAHLFCIRVL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RALGYAYINS | GQLEADDACA | NLYHTNTVAY | VHTTDTDLLL | MGCDIVLDIS | TGYIPTIHCR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DLLQYFKMSY | PQFLALFVRC | HTDLHPNNTY | ASVEDVLREC | HWTAPSRSQA | RRAARRERAN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SRSLESMPTL | TAAPVGLETR | ISWTEILAQQ | IAGEDDYEED | PPLQPPDVAG | GPRDGARSSS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SEILTPPELV | QVPNAQRVAE | HRGYVAGRRR | HVIHDAPEAL | DWLPDPMTIA | ELVEHRYVKY |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VISLISPKER | GPWTLLKRLP | IYQDLRDEDL | ARSIVTRHIT | APDIADRFLA | QLWAHAPPPA |
| 490 | |||||
| FYKDVLAKFW | DE |