AiPD: Autoinhibited Protein Database

Gene name	gyrB
Protein name	DNA gyrase subunit B
Names
Species	Staphylococcus aureus (strain N315)
KEGG Pathway	sau:SA0005
EC number	5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

1-49 (Predicted disordered autoinhibitory region) PR

1-49 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
2XCO	X-ray	310 A	A	410-644	PDB
2XCQ	X-ray	298 A	A	410-644	PDB
2XCR	X-ray	350 A	B/D/S/U	410-644	PDB
2XCS	X-ray	210 A			PDB
2XCT	X-ray	335 A			PDB
4BUL	X-ray	260 A			PDB
5CDM	X-ray	250 A			PDB
5CDN	X-ray	279 A			PDB
5CDO	X-ray	315 A	B/D/S/U	417-543	PDB
5CDP	X-ray	245 A			PDB
5CDQ	X-ray	295 A	B/D/S/U	414-543	PDB
5CDR	X-ray	265 A			PDB
5NPK	X-ray	198 A			PDB
5NPP	X-ray	222 A			PDB
6FM4	X-ray	270 A			PDB
6FQS	X-ray	311 A			PDB
6FQV	X-ray	260 A			PDB
7FVS	X-ray	216 A	A/B	409-644	PDB
7FVT	X-ray	208 A	A/B	409-644	PDB
8BP2	X-ray	280 A			PDB
AF-P66937-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Description	Diseaes Association	Provenance
No variants for P66937

Type	Name	Position	InterPro Accession
domain	DNA gyrase B subunit, C-terminal	574 - 634	IPR002288
domain	Histidine kinase/HSP90-like ATPase	39 - 183	IPR003594
domain	TOPRIM domain	429 - 543	IPR006171
domain	DNA topoisomerase, type IIA, subunit B, domain 2	232 - 401	IPR013506
conserved_site	DNA topoisomerase, type IIA, conserved site	433 - 441	IPR018522
domain	DNA gyrase subunit B, TOPRIM domain	429 - 542	IPR034160

		Description
EC Number	5.6.2.2	Enzymes altering nucleic acid conformation
Subcellular Localization	Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
chromosome	A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

Name	Definition
ATP binding	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding	Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2.
metal ion binding	Binding to a metal ion.

Name	Definition
DNA topological change	The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication	A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins