P66878
Gene name |
cobIJ (cobI, BQ2027_MB2092) |
Protein name |
Cobalamin biosynthesis protein CobIJ |
Names |
|
Species |
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97) |
KEGG Pathway |
|
EC number |
2.1.1.130: Methyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P66878
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P66878-F1 | Predicted | AlphaFoldDB |
No variants for P66878
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P66878 | |||||
No associated diseases with P66878
6 regional properties for P66878
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Tetrapyrrole methylase | 6 - 218 | IPR000878-1 |
| domain | Tetrapyrrole methylase | 249 - 456 | IPR000878-2 |
| conserved_site | Uroporphiryn-III C-methyltransferase, conserved site | 10 - 24 | IPR003043-1 |
| conserved_site | Uroporphiryn-III C-methyltransferase, conserved site | 103 - 135 | IPR003043-2 |
| domain | Precorrin-3B C17-methyltransferase domain | 249 - 492 | IPR006363 |
| domain | Precorrin-2 C(20)-methyltransferase domain | 5 - 236 | IPR006364 |
Functions
| Description | ||
|---|---|---|
| EC Number | 2.1.1.130 | Methyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| precorrin-2 C20-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A. |
| precorrin-3B C17-methyltransferase activity | Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cobalamin biosynthetic process | The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. |
| methylation | The process in which a methyl group is covalently attached to a molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSARGTLWGV | GLGPGDPELV | TVKAARVIGE | ADVVAYHSAP | HGHSIARGIA | EPYLRPGQLE |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EHLVYPVTTE | ATNHPGGYAG | ALEDFYADAT | ERIATHLDAG | RNVALLAEGD | PLFYSSYMHL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| HTRLTRRFNA | VIVPGVTSVS | AASAAVATPL | VAGDQVLSVL | PGTLPVGELT | RRLADADAAV |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VVKLGRSYHN | VREALSASGL | LGDAFYVERA | STAGQRVLPA | ADVDETSVPY | FSLAMLPGGR |
| 250 | 260 | 270 | 280 | 290 | 300 |
| RRALLTGTVA | VVGLGPGDSD | WMTPQSRREL | AAATDLIGYR | GYLDRVEVRD | GQRRHPSDNT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DEPARARLAC | SLADQGRAVA | VVSSGDPGVF | AMATAVLEEA | EQWPGVRVRV | IPAMTAAQAV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ASRVGAPLGH | DYAVISLSDR | LKPWDVIAAR | LTAAAAADLV | LAIYNPASVT | RTWQVGAMRE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| LLLAHRDPGI | PVVIGRNVSG | PVSGPNEDVR | VVKLADLNPA | EIDMRCLLIV | GSSQTRWYSV |
| 490 | 500 | ||||
| DSQDRVFTPR | RYPEAGRATA | TKSSRHSD |