P66015

PR
Gene name
relA (BQ2027_MB2614C)
Protein name
Probable GTP pyrophosphokinase
Names
(p)ppGpp synthase, ATP:GTP 3'-pyrophosphotransferase, ppGpp synthase I
Species
Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
KEGG Pathway
EC number
2.7.6.5: Diphosphotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-72 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P66015

Entry ID Method Resolution Chain Position Source
AF-P66015-F1 Predicted AlphaFoldDB

No variants for P66015

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P66015

No associated diseases with P66015

7 regional properties for P66015

Type Name Position InterPro Accession
domain ACT domain 709 - 788 IPR002912
domain HD/PDEase domain 101 - 224 IPR003607
domain TGS 450 - 511 IPR004095
domain HD domain 105 - 202 IPR006674
domain RelA/SpoT 273 - 403 IPR007685
domain RelA/SpoT, TGS domain 453 - 511 IPR033655
domain RelA/SpoT, AH and RIS domains 525 - 697 IPR045600

Functions

Description
EC Number 2.7.6.5 Diphosphotransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
GTP binding Binding to GTP, guanosine triphosphate.
GTP diphosphokinase activity Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

2 GO annotations of biological process

Name Definition
guanosine tetraphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEDQLTAQA VAPPTEASAA LEPALETPES PVETLKTSIS ASRRVRARLA RRMTAQRSTT
70 80 90 100 110 120
NPVLEPLVAV HREIYPKADL SILQRAYEVA DQRHASQLRQ SGDPYITHPL AVANILAELG
130 140 150 160 170 180
MDTTTLVAAL LHDTVEDTGY TLEALTEEFG EEVGHLVDGV TKLDRVVLGS AAEGETIRKM
190 200 210 220 230 240
ITAMARDPRV LVIKVADRLH NMRTMRFLPP EKQARKARET LEVIAPLAHR LGMASVKWEL
250 260 270 280 290 300
EDLSFAILHP KKYEEIVRLV AGRAPSRDTY LAKVRAEIVN TLTASKIKAT VEGRPKHYWS
310 320 330 340 350 360
IYQKMIVKGR DFDDIHDLVG VRILCDEIRD CYAAVGVVHS LWQPMAGRFK DYIAQPRYGV
370 380 390 400 410 420
YQSLHTTVVG PEGKPLEVQI RTRDMHRTAE YGIAAHWRYK EAKGRNGVLH PHAAAEIDDM
430 440 450 460 470 480
AWMRQLLDWQ REAADPGEFL ESLRYDLAVQ EIFVFTPKGD VITLPTGSTP VDFAYAVHTE
490 500 510 520 530 540
VGHRCIGARV NGRLVALERK LENGEVVEVF TSKAPNAGPS RDWQQFVVSP RAKTKIRQWF
550 560 570 580 590 600
AKERREEALE TGKDAMAREV RRGGLPLQRL VNGESMAAVA RELHYADVSA LYTAIGEGHV
610 620 630 640 650 660
SAKHVVQRLL AELGGIDQAE EELAERSTPA TMPRRPRSTD DVGVSVPGAP GVLTKLAKCC
670 680 690 700 710 720
TPVPGDVIMG FVTRGGGVSV HRTDCTNAAS LQQQAERIIE VLWAPSPSSV FLVAIQVEAL
730 740 750 760 770 780
DRHRLLSDVT RALADEKVNI LSASVTTSGD RVAISRFTFE MGDPKHLGHL LNAVRNVEGV
YDVYRVTSAA